Hydrogen, Caffeine, and Energy: It’s no surprise that many people are running low on sleep. Breakthrough science on sleep-deprived humans has explored the link between caffeine, hydrogen, and alertness. Today we unpack the new study and explore ways you can learn to get the most out of your energy depending on your bio-individual needs.
Hydrogen, Caffeine, and Energy: The Science
A new 23-subject crossover study published in the scientific journal Neurophysiology comparing the efficacy of Drink HRW hydrogen tablets vs. caffeine using the ‘Attention Network Test’ designed to measure alerting, orienting, and executive control. 
The results determined that high dose hydrogen water produced by Drink HRW hydrogen tablets were statistically equivalent to 100 mg of caffeine (roughly a cup of coffee). 9 of the 23 subjects responded significantly better to hydrogen water than caffeine, while only a few responded to caffeine better than hydrogen water (the remainder had no statistical difference).
Furthermore, the study highlighted some of the critical differences in the types of attention that were altered. Caffeine was very effective in alerting, whereas hydrogen water had little to no impact. Hydrogen water was very useful in orienting, whereas the caffeine had little to no effect, and both were effective in executive control, although caffeine was more effective in this measurement.
All in all, hydrogen saw a more significant trend towards improvement over baseline. Still, taking into account the statistical significance between caffeine and hydrogen water, the two treatments were almost identical in efficacy. These are significant findings, and if replicated and expanded on, hydrogen water could be utilized with caffeine for an additive or even synergistic benefit.
Hydrogen, Caffeine, and Energy: Caffeine vs. Hydrogen
Before choosing an energizing protocol that works for you, it’s important to understand the properties of both substances and the impact that they may have on your body, both short and longer-term.
The brewed drink made from roasted coffee beans is generally sought out as a beverage due to its caffeine content. Caffeine is a central nervous system stimulant and is the world’s most widely consumed psychoactive drug in the world. 
Short term: Caffeine is rapidly absorbed from the gut into the bloodstream, traveling to the liver where it is broken down into various compounds. Drowsiness is caused by adenosine, but caffeine binds to adenosine receptors, effectively blocking adenosine out. By blocking adenosine receptors, coffee prevents drowsiness. 
Longer-term: The half-life of caffeine is about 5 hours, so if you consume 40mg of caffeine at 8 am, 20mg of caffeine will remain in your bloodstream around 1 pm, and 10mg at 6 pm. 
- A quick boost in alertness (caffeine takes about 20 minutes to hit the bloodstream)
- A zero-calorie appetite suppressant for use during the fasting window
- It may increase adrenaline levels in the blood, which can lead to an increase in mood-boosting dopamine and norepinephrine levels.
Cautioned use for:
- People with sensitive insulin responses to caffeine
- People with routinely poor sleep hygiene
- People with more severe adrenal/ hormonal issues (like adrenal fatigue)
- Use in the afternoon/ overuse in general.
Hydrogen is a colorless, odorless, and non-toxic gas that can bind with other elements like oxygen, carbon, and nitrogen to form various compounds. Many people know that the molecular structure of water is H2O, and indeed, hydrogen is composed of the same two hydrogen atoms, without the oxygen atom. 
Hydrogen is one of the most widely researched elements that support a wide range of disease models when ingested. As the smallest known molecule, scientists suggest that it can penetrate every organ and cell in the body with its benefits, including potent antioxidant and anti-inflammatory properties.  There are various ways to ingest H2, the most common being hydrogen-rich water, whereby H2 tablets are added to water to increase its hydrogen content.
Short term: The consumption of hydrogen-rich water has been linked to many benefits, including rapid increase of ability to orient, and a general improvement across an array of alertness factors according to the ‘Attention Network Test’ (that measures alerting, orienting, and executive control). 
Long term: The science highlights the profound long-term results that hydrogen-rich water can have on a wide-range of bodily processes. A two-month HRW protocol significantly reduced serum malondialdehyde, interleukin-1, interleukin-6, tumor necrosis factor-α levels, and significantly increased serum superoxide dismutase, total antioxidant capacity levels, and hemoglobin levels of whole blood. The consumption of hydrogen-rich water improved the diversity and abundance of gut flora. 
The long-term use of hydrogen has no known negative side-effects. Still, its high antioxidant content has been linked to fighting free-radicals in the body and reducing inflammation and oxidative stress. 
- A quick boost in orienting skills
- People who are sensitive to caffeine
- People dealing with metabolic syndrome and weight loss resistance
- People who are dealing with adrenal or hormonal issues
- An afternoon pick-me-up
- Athletes, to promote faster recovery
Cautioned use for:
- There are no known adverse side effects for the consumption of hydrogen-rich water.
Hydrogen, Caffeine, and Energy: Which to Choose?
Well, first off, you don’t have to choose between the boost that you get from coffee or hydrogen. The two can be used at the same time for slightly varied, synergistic effects. Factors that may suggest the use of hydrogen alone over a combination of the two includes sensitivity to caffeine, poor sleep quality/ circadian rhythm, or adrenal/ hormone issues. Since caffeine stimulates the central nervous system, it can prove to cause more harm than good for someone who is already on overdrive.
Hydrogen alone may also be a better option for a mid-afternoon boost, instead of reaching for sugar, or caffeine to get over that afternoon slump. Since caffeine has a relatively long half-life, using it later in the day (even if you’re a fast metabolizer) will likely impact the quality of your sleep and leave you reaching for even more coffee or sugar the following day.
There are various ways to increase energy levels after a night of poor sleep. Using caffeine is one of the most popular ways. Still, the latest science suggests that hydrogen may be more beneficial than caffeine for an increase from baseline across all markers for alertness according to the alertness and on Attention Network Test (ANT). Understanding the cause and effect of both caffeine and hydrogen can help you decide which can best serve your bio-individual needs, or how to use them together for amplified and synergistic benefits.