Senescent cells are cells that live too long, causing us to age prematurely, but also cause disease and a dysfunctional immune system. You will learn some unique strategies to approach our immune function in this episode. Today I'm interviewing a top stem cell doctor and biologist, Dr. Rafael Gonzales. From what's legal in our country, to where you can actually go for stem cell treatments, and a special deal for you – all in today's episode.
More about Dr. Rafael Gonzales, PhD:
Dr. Gonzalez obtained his PhD and BS from the University of California, Irvine where he studied, and his thesis addressed interactions of the immune system following spinal cord injury. In addition to his expertise in degenerative disorders involving the spinal cord, he has extensive experience in stem cell culture and biology from human embryonic, pre-natal and adult sources. Presently, Dr Gonzalez is responsible for the development of clinical stem cell applications for several disease/trauma states. Moreover, he works on clinical development of immune based therapies using natural killer cells. Dr Gonzalez has been in the stem cell field for greater than 17 years and has several scientific publications. In addition, he has taught, spoken and led many conferences nationwide in the regenerative medicine sector.
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Transcript:
Dr. Pompa:
Have you heard of the word senescent cells? That means cells that live too long cause us to age prematurely but also cause our immune system not to work correctly. Oh, that’s been all over the news lately, trust me. You’re going to learn more and some unique things that we can actually do about it in this episode. Stem cells, wait ‘til you hear this new study. I’m interviewing Rafael Gonzalez, one of the world’s top stem cell biologists, and we’re also going to talk about natural killer cells.
Wait ‘til you see the study that Merilee and I were involved in and what it did for senescent cells. There’s a lot to this episode. What’s legal in the United States? What can you actually go to Mexico and get to help some of these conditions that we’re going to talk about on this episode, can’t wait for you to hear it? This is one of the top people in the world, and this is one of the most important subjects in what I believe is the future of medicine. Stay tuned.
Thanks for being here.
Dr. Gonzalez:
Thank you very much for having me. I really appreciate it. It’s a pleasure.
Dr. Pompa:
Absolutely, all right, well, we’re here actually on location, and this is a great, great topic today. I tell you, you’re going to be blessed. These are things that many of you ask about, actually. We’re going to have an in-depth talk about stem cells. We’ve done some shows in the past and even some Facebook Lives because this man has made such a difference in my life and many of you watching. Some of you have gone to Mexico and have been blessed by this man’s brilliance in cells, stem cells, but we’re going to talk about a study that I’ve been blessed to be part of and Merilee. As a matter of fact, you’re going to see our results from something called natural killer cells so stem cells, natural killer cells.
Look, Rafael, my interest in these topics is aging, slowing the aging process. I always say, look, I don’t want to live to 150 like some people say they want to live. I don’t. If you gave me 90 years perfectly healthy without disease, mountain biking, skiing, everything, I would take that deal. The point is is that I—the perfectly healthy is the key.
Dr. Gonzalez:
Yeah, it is, 100%.
Dr. Pompa:
Yeah, we’re going to talk about something they call senescent cells. Senescent cells mean that cells that live too long and cause a lot of mischief and problems in our body and how we can really change that. Ultimately, when we look at people who live long healthy, well, they don’t have many of these types of cells, so we’re going to talk about that and how to get rid of them. Rafael, first of all, tell them—let’s just discuss a little bit about stem cells. This is part of what you do, and we’ll get to that natural killer cells and the study and what we did in a minute. Wait ‘til you see these results.
Dr. Gonzalez:
We’ve been doing stem cell work for about—I’ve been working actually in the field for about 20 years now, but we’ve been doing it in our Cancun clinic working about 12 years now over there doing stem cell work. We do what’s called a—it’s a different, more personalized approach. First and foremost, assessing the patients, what’s going on, which you know every single one of us are completely different, and it’s probably the most important aspect of the job of what we actually do or what the clinicians actually do out there is assessing what’s transpiring with the patient. We always know that even in every single disease there’s an inflammatory component to it, and we want to deal with the inflammatory component of it. We have a particular cell type that we work with quite a bit that’s from umbilical cords and mesenchymal stem cell that actually controls the immune system significantly and does quite a bit of work with doing that. One of the most important things it actually does is it increases our regulatory system. The reason why a lot of people have a lot of havoc in their immune system is because the immune system’s not regulating correctly.
There’s a particular cell that’s called a CD25 regulatory T cell. That T cell is the one that surveils on a regular basis and tells you you have an overactive immune system or you have an underactive immune system, and it helps to regulate that system, our system we have. One of the things that these stem cells actually do is actually keep those increased, keep those in check, and make sure that there’s significant amount of them that they can actually do what they need to do.
Dr. Pompa:
We’ve had many people who watch this show actually go down and get this treatment that have had autoimmune conditions that just seemingly impossible for their body to fix or shut down the autoimmune. Basically, what you just described is why they went for some of these treatments that you’re able to do in Mexico. I want to be clear. First of all, stem cells are legal in this country, but what’s not legal is taking a stem cell either from yourself or from an umbilical cord and expanding the cells.
Dr. Gonzalez:
Correct.
Dr. Pompa:
First of all, you’re allowed in this country to expand cells. You’re just not allowed to inject them back in your cells.
Dr. Gonzalez:
Correct, yeah, you’re allowed to do the research and you’re allowed to do clinical studies, which is what’s being done now in many cases. A lot of clinical research is actually being done, and that’s what transpires, including us. We have a clinical study ourselves that’s on what’s called acute respiratory distress syndrome due to COVID, if you have COVID.
Dr. Pompa:
Yeah, exactly, we’re going to talk about that, yeah.
Dr. Gonzalez:
That’s one thing, and then we also have one on polymyositis, dermatomyositis, which is actually an autoimmune disease that causes pulmonary fibrosis.
Dr. Pompa:
Look, that’s the thing is that you could get your own stem cells injected in the United States, but you can’t expand them to the levels that we need for some of these conditions, very complicated conditions. You have to go to Mexico to do that which, by the way, because of the COVID situation, they’re offering, which is incredible because of the amount of work that goes behind this, 25% off any treatment that we discuss on this show today. You can actually go to Mexico like I did and many of you and actually get 25% off because they’re—Mexico, literally…
Dr. Gonzalez:
Yeah, I mean, everything’s been shut down. Everything’s been difficult, and now there’s so many safety precautions that are actually being done and a lot of safety precautions that…
Dr. Pompa:
Right now it’s easy to travel into Mexico.
Dr. Gonzalez:
It’s easy, really, really easy to travel into it and actually really comfortable because there’s not that many people there.
Dr. Pompa:
Yeah, and 25% off any of the things that we talk about. Ashley will provide the link for you, and you can just mention that you saw this show. You could write my name, Pompa, or CellTV when you go there to fill out. I think you all offer a free consultation.
Dr. Gonzalez:
Correct, yeah.
Dr. Pompa:
Yeah, so you get the free consultation with whatever condition you’re dealing with. See if it’s something that would help you, mention the show, and if you decide to get the treatments that they offer there, then you would get 25% off. I want to talk about the study you’re doing. Right now, a lot of people are very concerned, and again, we can’t make any claims. Right now anything that talks about a claim for COVID or something, that’s getting shut down. However, you are allowed to talk about your study that you’re doing.
Dr. Gonzalez:
Yeah, absolutely.
Dr. Pompa:
Because you said that these cells have such a dramatic effect on the immune system, then this is what really triggered the study. You’re allowed to talk about that.
Dr. Gonzalez:
As everybody’s hearing, a lot of the problems with COVID-19 is one of the last things that actually occurs, what’s called a cytokine storm. This is actually very, very common when your immune system is basically on overload. These cytokines are basically protein signalers in the body that are released mostly by immune cells that start saying we need to work and do—clean this up, do that, do that. Over activate the immune system, or keep the immune system in check. When there’s many different things going on at one time in this system, which is what’s been happening, which individuals that have—once they have respiratory distress syndrome, once the kidneys possibly get involved, once the heart gets involved, etc., etc., it goes on the line. It basically ends up being what’s called the cytokine storm. A storm comes in, and the storm is what actually has been noted to kill a lot of individuals and cause massive issues. One thing that stem cells does really, really well is actually…
Dr. Pompa:
Even permanent damage in the lungs, right?
Dr. Gonzalez:
Correct, yeah.
Dr. Pompa:
Which is a problem later.
Dr. Gonzalez:
Yeah, so one of the ways to address is—it’s very well documented that stem cells actually do a fantastic job of suppressing this really strong response, the cytokine response that actually happens. One of the methods is, like we just said, increasing that regulatory system, so it recognizes that you don’t want to cause too much havoc in here. That’s one of the mechanisms that it actually does. Another thing it actually does is increases blood flow and vasculature. Many people have been reading out there of people having strokes, heart attacks, etc. If you have an increased blood flow, this actually can help with it. It’s one of the methods that we’ve actually been addressing, and we’ve looked at COVID. We have an FDA approved study, a Phase I, to a multicenter study that we actually have and been progressing forward with and have had great results with so far.
Dr. Pompa:
Yeah, so I mean, right now, again, the only way he’s—we’re able to talk about it is because they’re actually doing the study. So far the study—what phase is it in?
Dr. Gonzalez:
Right now it’s in Phase I.
Dr. Pompa:
Phase I, yeah, Phase I.
Dr. Gonzalez:
It’s Phase I right now. Once we finish the Phase I portion, then it’ll go into a Phase II. That’s actually a blinded study. It’s what called the [31 design] blinded study where 30—excuse me, 75% of the patients actually get a treatment, and then 25% don’t.
Dr. Pompa:
Again, so what I want you to hear in here also is the impact that these cells can actually have on the immune system, and that’s why it’s helped so many with, again, the overactive immunity and shutting that down. Again, I think, when we talked about stem cells in the past, we get—there’s a lot of confusion. There’s autologous stem cells, meaning you take your own stem cell and inject it into a knee or shoulder. This is different. Explain the difference of using say from an umbilical cord and expanding that. Explain the difference in someone—in why this type of cell would be better for someone who has a health condition versus just a sore joint.
Dr. Gonzalez:
Yeah, so stem cell as a term is very loosely used. If you think of what you hear about using stem cells for a joint out there, that it’s done actually right in the United States, it’s from bone marrow. The percentage actually of stem cells that are actually in there is less than .00001%, so you’re talking about 10 to the negative 5th amount of stem cells.
Dr. Pompa:
In other words, if I went and they took my own stem cells out, which is…
Dr. Gonzalez:
The bone marrow.
Dr. Pompa:
…bone marrow, which is legal here in the United States, and then injected it in a sore joint, that’s how many stem cells are in it. It’s still a good procedure.
Dr. Gonzalez:
It’s still a good procedure, and it works well because there’s other cell types in there. There’s endothelial progenitor cells. There’s other immune cells that can help regulate and actually help regenerate. It’s a regenerative medicine product in general. Something else that you will hear about is you do a fat extraction, and you isolate what’s called a stromal vascular fraction. Just exactly like it says, it’s stromal, meaning fibroblastic origin; vascular, meaning vascular origin, and then fraction.
Dr. Pompa:
There’s more stem cells in your fat.
Dr. Gonzalez:
There’s more mesenchymal stem cells in your fat, but it’s still a very low percentage in the negative—like 10 to the negative 3rd or 10 to the negative 4th percentage in total of the cells that are actually in there. When you take fat out and you have fat cells, you have endothelial cells. You have these stromal cells. You have stem cells in there and other cell types that are actually in there. Immune cells are actually in there too. It’s a really, really small fraction. Nevertheless, it’s a regenerative medicine product because it causes regeneration. There’s evidence that shows it can cause regeneration. Then the next level is when you use, basically, allogeneic products such as…
Dr. Pompa:
Allogeneic means it comes from someone else.
Dr. Gonzalez:
Means from someone else, from somebody else, from somewhere else. It’s not yours. Autologous is yours. Allogeneic is somewhere else. These are normally post-birth products that we know about and even actually bone marrow products. Sometimes they take a young bone marrow, and they produce a large line of these. They use them in many patients. There’s a lot of large companies that actually do this out there, large mid-cap biotech companies that actually do this.
You can actually take and purify a mesenchymal stem cell even though it’s in a low percentage, whether it be from umbilical cord tissue, placental tissue, amniotic tissue, bone marrow or fat, and you can take that and expand that out. What it’s basically is just basically these things adhere to plastic, like a petri dish. Then it grows. They multiply and multiply and multiply. They make clones of themselves. They multiply out, and these are the purified stem cells that we actually use. In our case, we use it from umbilical cord tissue.
Dr. Pompa:
Right, after birth.
Dr. Gonzalez:
After birth.
Dr. Pompa:
People think, oh, my gosh, your aborting babies. That was the old days.
Dr. Gonzalez:
No, correct. No, these are actually signed informed consents that mother will give. A mother’s assessed really, really well to make sure they don’t have any viral loads, any viruses, any bacterial. The products are normally tested very, very—they are tested very, very rigorously.
Dr. Pompa:
I did a show where I looked at the testing that goes into these cells. It was pretty dramatic. Talk about the pros and cons to this, though. I mean, again, it’s the wild, wild West out there with stem cells. People go to doctors. This Dr. X is using a product like that. You know as well as I know that it’s not always viable or even worth anything.
Dr. Gonzalez:
You have to verify it. You got to verify testing that’s been done. Looking at viability, quantity of cells, quality of cells, how much testing has been done on the cells. Looking at what’s being secreted. We all know now that the mode of action is basically what’s secreted from the cell too, looking at that, and then looking at old versus young. We all know that we’ve been—we’ve had exposure. We’ve had exposure to anything that you can think of out there. Some of us have autoimmune diseases. There’s a significant amount of evidence that using cells from yourself if you have an autoimmune disease is not effective. It’s both actually shown in animal models and, believe it or not, in actually humans too.
That’s why we take a younger source. Remember, when we’re younger, we are less prone to having all these different diseases. It’s a naïve, very young cell that is vibrant; grows very, very well. The productions that we can do are a lot better and the secretome, what’s being secreted out, specifically when used, for instance, umbilical cord. I mean, if you think of the umbilical cord, it’s a fountain in between mother and child. It has to sustain a life throughout life, and it has to have immune properties. Remember, baby is also part of father. Baby cannot be rejected while it’s inside a mom, and this requires immune capabilities that basically allow for there not to be a rejection. That’s why that fountain is actually really, really, really strong fountain of—with immune properties, and this is something that we actually use regularly. We test, overstress it.
Dr. Pompa:
I had these cells. By the way, these are the only cells besides my own that I would ever utilize because I know where these cells have come from, which is very important. The point is is that they’re young. They’re vibrant, and they communicate. Basically, when they go into your body, they’re triggering. They’re releasing something called exosomes that communicate to your cells to start healing again, to get you younger again.
I think one of the best examples I had given people in the past is—this was one of the first things, studies, but they sewed two rats together, a young one and an old one. The old rat just because they share these types of cells became younger, I mean, on every blood test. Basically, when you’re putting these cells into your body, a very similar thing is happening, right?
Dr. Gonzalez:
Correct.
Dr. Pompa:
It’s communicating youngness, if you will, but it’s downregulating autoimmune, hyperimmunity. It’s regulating the immune system, as you said.
Dr. Gonzalez:
It’s also cells are, I mean, in our body and outside of our body. When we culture them, they strive to survive. Just like, for instance, somebody has a heart attack and the body goes into autopilot mode of survival. When you put cells somewhere, it says, whoa; what’s going on in here? I need to survive. I need to figure out a method of survival, and the only way I can do that is by adjusting and releasing out of my cells what my partner, the other stem cell next door needs, and what I need to regulate the body. I have to regulate, and I have to put the body in homeostasis. Eventually, it’s just basically these things become factories of releasing factors, factors, factors, factors until eventually they say, uh-oh, I can’t survive anymore because I’m not in the right environment, but they’ve done the correct job of changing that environment to put it into a homeostatic state.
Dr. Pompa:
Yeah, that’s cool. Yeah, so again, where many people have responded to our shows in the past is going to get these cells for that, what we’re talking about, that downregulation of hyperimmunity, the upregulation of good immunity. Of course, there’s antiaging properties all over this, same thing.
Dr. Gonzalez:
Yeah, which is regulating the immune system in general. Ultimately, cosmetically, which will lead to our next sector sort of, is you get senescence everywhere. I mean, gray hair is senescent cell. It’s basically a cell that’s multiplied, multiplied, multiplied, and then it no longer releases the pigment. Ultimately, we want to maintain—in this case is maintaining a young immune state, so internally, we can feel good. Everybody knows you can do whatever you want cosmetically outside and feel better, but ultimately, you want to feel good internally.
You want to be able to exercise, and you want exactly what we discussed. It’s having good lifespan. It’s living to that 80, 90, 100 where you can continue to walk. You can go to the beach. You play golf. You can do whatever you want to do, but do it that you feel comfortable and you feel good.
Dr. Pompa:
It’s why I do it, I mean, honestly. I mean, I think right now we’re in one of the most exciting times in history with the ability to utilize these cells. I’ve spent a lot of time reading these studies. That’s how I found this guy, actually. I found his name on a study. I don’t know. I think I just reached out. One of your people reached out back to me. I literally was like I want to know more about this.
Anyways, I had been into stem cells for many years now because I think it’s the future of medicine. I really do. In this country, obviously, things have slowed up with this more systemic use of stem cells, but you can go the Mexico clinic, which is your research, part of your research.
Dr. Gonzalez:
Yeah, absolutely, and you can get things—we do things there according to the regulations that are actually…
Dr. Pompa:
Yeah, according to the regulations.
Dr. Gonzalez:
According to regulations that are actually over there and according to the approvals that we actually have that we can do.
Dr. Pompa:
You’re connected to one of the largest hospitals or at least one of the best hospitals.
Dr. Gonzalez:
In Cancun, yep.
Dr. Pompa:
In Cancun. It’s so easy to fly into Cancun, by the way.
Dr. Gonzalez:
Yeah, it’s not a bad place to go. It’s beautiful.
Dr. Pompa:
No, I know it is. I look for reasons to go. Yeah, no, it’s very easy, and you have blessed so many of our viewers, honestly. I’ve heard the stories. Just to show you, I know you—we don’t want to violate a HIPAA, so you can just speak about this gentleman. I think he was an ex-runner. I mean, he became this older gentleman, arthritic. It got to the point where he wasn’t able to run, even in a wheelchair, and he started doing these stem cells. Tell that story there.
Dr. Gonzalez:
Yeah, he started doing cellular therapies in general, and we started analyzing, looking at senescence, which is something we’ll show you soon with both Dan and Merilee.
Dr. Pompa:
Yeah, cells that live too long.
Dr. Gonzalez:
Cells that live too long and just occupy space and release what’s called senescent-associated factors and you can look this up. There’s a lot of data out there that show that these senescent-associated factors indirectly or directly actually cause Alzheimer’s, dementia.
Dr. Pompa:
Yeah, of course, yeah.
Dr. Gonzalez:
Anything you can think of, heart disease, etc.
Dr. Pompa:
Cancer.
Dr. Gonzalez:
Yeah, cancer, etc. We have evidence that—we’ve done some therapies on them that we’ve actually decreased this, and even I looked at telomerase and telomere studies on it too. Significantly decrease it where he got to a point that as an 80-something or 85-year-old now that is running 3 to 5 miles every day.
Dr. Pompa:
Yeah, he was so arthritic. He couldn’t even barely walk.
Dr. Gonzalez:
Yeah, so we see that. It’s surprising. We see things like this not happen 100% of the time. Ultimately, it deals with many things. You got to diet the right way. I mean, this is not a cure-all, a heal-all. This is a change of life, and it requires other factors that you actually maintain that you have to do. As we age, we have to make changes in our lives.
Dr. Pompa:
Absolutely, you can’t put new wine into old skins and expect it just to be magical, but if we give our new—if we give the body what it needs and then we put the new wine in, magic can happen. Yeah, so let’s shift to this senescent cell thing. Senescent cells, I had read—when COVID first started, I read some great articles saying this is really the problem. The gentleman talked about immuno-senescent cells, meaning immune system cells that live too long. They create mischief. They drive inflammation. His point was, if you’re a 35-year-old and you have an extremely negative reaction to COVID or a harsh time with it, they—basically, he’s saying that you have too many immuno-senescent cells. By the way, when you—the older you get, the more immuno-senescent cells you develop. That’s why COVID is way more deadly for someone older. It’s because they have a lot of immunosuppressant cells—senescent cells, sorry. Young people with different conditions can have a lot of these cells, and then they react to this.
Now, just in general, these cells, I call them government workers. I’m probably insulting someone out there. I apologize. Let’s not say every government worker. The joke and the funny thing is there is that they just want to sit around do nothing. That’s the biggest problem. They recruit their friends to do nothing.
Dr. Gonzalez:
Yeah, they do recruit their friends to do nothing.
Dr. Pompa:
Meaning that so, these cells, they don’t—these cells in your body that want to do nothing, if they’re an immune cell or if it’s a cell that’s meant to heal something, they just don’t want to do anything. Here’s the problem. They convince the other cells around you don’t do anything. We don’t need to do anything, and then you end up with disease problems, etc.
Dr. Gonzalez:
They’re just signalers. These natural killer cells as we age has become signalers that are not efficient signalers. In science, these are actually called CD56bright cells. They are the ones that—they’re signalers, and that’s about it. What we want is these CD56, them natural killer cells that are the attackers, the go-getters. It’s the ones that when you’re younger you have an abundance of them. That’s why you’re less prone to get cancer because this is the first responder to cancer.
Dr. Pompa:
It protects you against viruses, cancer.
Dr. Gonzalez:
Yeah, and senescence. It’s the three things that it actually deals with. When you’re young, they’re strong. We spent years studying them before we said, okay, let’s move forward with doing a clinical on it or doing any work on it, finding ways to expand them from you so autologous therapy.
Dr. Pompa:
Meaning, yeah, take your blood.
Dr. Gonzalez:
Take your blood.
Dr. Pompa:
Isolate these natural killer cells, which are the first line of defense, if you will, the innate immune response, right?
Dr. Gonzalez:
Yeah, and then expanding them up and purifying them and making them active, which is the most important component of it, activating them to a younger state that they’re killers again. The concept behind that is, basically, I need that NK cell to go into your system and do what it’s supposed to do the right way, which is, number one, wipe out any problems that are there with viruses, which we’ve had some work with viruses before, wipe out any cancerous possible cells that are in there. If you look up the field, it’s over 1500 studies in cancer. If you look it up in clinicaltrials.gov with NK cells, that’s mostly the focus, but lastly is wiping out that old deficient immune cell that’s in our body. That’s not doing anything. It’s not. If we do that, we now cause what he just showed you a little while ago with—what he discussed with the mouse, one connected to another. It forces your bone marrow to secrete out the stem cells that are just sitting there dormant, regeneration. It has to.
Dr. Pompa:
You develop new immune cells.
Dr. Gonzalez:
You have to develop.
Dr. Pompa:
Hard workers.
Dr. Gonzalez:
Yeah, you have to develop young ones because the bone marrow, the niche now becomes activated and says I need to secrete out the right things, the young cells again.
Dr. Pompa:
I want to pull you back here a second because I felt like we shifted gears so quickly. The reason I started talking about these old cells that live too long, senescent cells, is because, okay, you talked about—we talked about the stem cells. That’s one treatment or procedure, but now we’ve moved over to natural killer cells. What we’re talking about now is—and Merilee and I have been part of a study in research that Rafael is doing, and what happens is they’ve taken our blood. Now, you’re going to see in a moment our results in how they affected our bad cells, our senescent cells. They’ve taken our blood. It takes about three weeks to a month. They harvest out your natural killer cells, and then they multiply them. It takes about a month, and then they get a larger number of these things, in the billions, right?
Dr. Gonzalez:
Right, in the millions.
Dr. Pompa:
From the millions to billions.
Dr. Gonzalez:
From about 25, 30 million to anywhere from 1 to 2 billion.
Dr. Pompa:
Yeah, and I think Merilee and I almost have about two billion each time.
Dr. Gonzalez:
Two billion each time, yeah.
Dr. Pompa:
Then what happens is—now, let’s be clear. You cannot inject that in the United States. That’s why we went to Mexico, and we were able to get these put back in us. These were our own cells, our own natural. We call it expanded and then put back in. These natural killer cells activate our—make our immune system young, I mean, basically, and then they eat up these senescent cells. You could explain what we did here.
Dr. Gonzalez:
I’m actually going to show you—I’m going to share my screen with you just to show you some graphs so that you can take a look at. You can see right here MP and DP, Merilee and then Dan.
Dr. Pompa:
Merilee and I have been in very good competition with this, by the way.
Dr. Gonzalez:
What we’re basically looking at and I’ll use the arrow pointer right here is, first and foremost, we’ll look at what’s called p16. P16 is a cell cycle checkpoint inhibitor that actually stops cells or lets cells continue to the divide. This is prior to their first treatment that they actually did as zero days. This is the p16 level that, for instance, Merilee had.
Dr. Pompa:
Okay, let me just be clear because I’m thinking like they’re thinking. Okay, so a p16, this is just something to measure in the blood that would—basically, if you have a lot of this would indicate…
Dr. Gonzalez:
You have a lot of senescence.
Dr. Pompa:
A lot of senescent cells. If you lessen it, that would mean you drop dramatically. I mean, I don’t want to say a one to one, but there’s a direct correlation of this enzyme. This is an enzyme?
Dr. Gonzalez:
It’s a protein.
Dr. Pompa:
Oh, it’s a protein, this protein and your natural—or I’m sorry, your senescent cells.
Dr. Gonzalez:
Your senescent cells. The first two graphs you see is p16. You will see at 56 days out a significant decrease in their p16 values, right?
Dr. Pompa:
Right.
Dr. Gonzalez:
Then all of a sudden at—this is in Merilee’s case. At 192 days out, this thing increases, so 192 days later it increases. Actually, in this case, it was higher than it was before in Dan’s so meaning something was going on with Merilee that she started getting, which you—we had discussed before, which is virus, etc., etc.
Dr. Pompa:
She had viruses. She had some infections, yeah.
Dr. Gonzalez:
Yeah, so she got a lot higher, but Dan still maintained lower than his baseline level. We come here, and we do another infusion of NK cells. This is their baseline. This is her baseline. This is his baseline.
Dr. Pompa:
Mine goes up, rose up a little but not to baseline and then dropped dramatically.
Dr. Gonzalez:
Yeah, and then here we go—the second treatment apparently looks like it’s a lot more effective. Here we go 18 days out because 18 days out you’re going to see almost everything removed. Still, look at 109 days out, and it maintained in Merilee, the levels; really, really low levels. Yours start to creep up at 109 days. Now we just did some bloodwork, which is now going to be probably in the range of about 200 days out, and we’ll actually have a look at that and see where we’re at with that level prior to doing another one.
Dr. Pompa:
The cool thing is as I want to say is that those are blood levels right there of a very young man.
Dr. Gonzalez:
Correct.
Dr. Pompa:
I’m 55 years old. I’m not that guy that you see there, but I became that guy.
Dr. Gonzalez:
Yeah, so it’s reduced his. If we look at in context of other people that we’ve done, his senescent levels have gone down to that of about—after the treatment, about that of about 30-year-old. To support that data, we’ve actually gone one step above, and we looked at this marker right here, beta-galactosidase senescence, which is basically an enzyme that’s only secreted out by senescent cells.
Dr. Pompa:
Senescent cells.
Dr. Gonzalez:
It’s an enzyme that’s secreted out. This is the before on Merilee, and then after the treatment, it goes down. Then exactly like what you see above here, it went way up.
Dr. Pompa:
Yeah, I mean, it paralleled.
Dr. Gonzalez:
Yeah, it parallels. Then it goes down again, and then it starts to feed back up. In Dan’s case, it’s the same thing. It’s the same pattern. It starts to go back up but not to the level where it was before. Then it goes down significantly at 18 days, and then it starts to creep back up. The next time point will be out here that we’re actually doing. We just did some bloodwork for this recently, and we’ll have a look at these same exact markers, which we’ll report three, six months down the line again to see what we get. We’ll see where we’re at. Ultimately, this actually demonstrates to you that this does—it removes adrenal senescence in the body.
Dr. Pompa:
Yeah, that’s really cool. Obviously, I mean, when I went on, I think there was—at the time when I was really researching this, there was probably—I think there was 852 studies on [00:31:51].
Dr. Gonzalez:
Yeah, there’s a lot more now.
Dr. Pompa:
There’s a lot more now. That was a while ago, but my point was is I literally got addicted to looking at these studies about natural killer cells. One thing I found because some of you might say, well, was there was side effect, no one developed anything bad.
Dr. Gonzalez:
No, there’s no side effects to this.
Dr. Pompa:
Yeah, it’s like so that was the good thing, as well as the stem cells too. Of course, one of the questions I had too is, well, wait a minute. I’m injecting this young cord cells in me, expanded out. They’re not mine. Is there any harm to that? I mean, I couldn’t find anything because rumors go.
Dr. Gonzalez:
If you look at—out of China, there’s a group that has been using umbilical cord MSCs for a really long time.
Dr. Pompa:
Long time.
Dr. Gonzalez:
Mostly on autoimmune diseases. These are published studies that are out there, and they’ve tracked for many years over 1,000 patients. In just that group alone, there has been no incidents of cancer of the [00:32:48] formation or anything like that. If you think of probably—I mean, I have to take a wild guess at this. Probably 20, 30,000 people have had this done, and there hasn’t been any reports of anything like that.
Dr. Pompa:
Yeah, and most of what they actually use for is cancer, to get rid of cancers. Yeah, so that’s something to keep in mind but two different things. Giving stem cells, it activates healing in your body versus natural killer cells, which work more with the immune system, but it’s still systemically. I mean, it’s affecting everything, I mean, general inflammation, etc., so two different things. We appreciate you bringing this information.
Dr. Gonzalez:
I appreciate the opportunity to share this.
Dr. Pompa:
Yeah, I mean, these are two things that I think people need. Grant it, I want to be clear. These aren’t cheap, the procedures.
Dr. Gonzalez:
No, they’re not.
Dr. Pompa:
They’re life-changing. There’s some people that, believe me, have responded to these in the past that didn’t necessarily have the money to do it but they had to do it type of thing. The research is here. I think this is the future of medicine.
Dr. Gonzalez:
It is. I think so too.
Dr. Pompa:
Yeah, I believe it. I appreciate your research because that’s what you do.
Dr. Gonzalez:
Thank you.
Dr. Pompa:
The new studies, I think even this new COVID study, it’s really—it’s going to basically give us more information beyond COVID about some of these things that we are worried about in the future.
Dr. Gonzalez:
Yeah, absolutely.
Dr. Pompa:
Stem cells, natural killer cells are part of the answer here.
Dr. Gonzalez:
Yeah, it is, cell therapeutics in general.
Dr. Pompa:
Yeah, cell therapeutics in general, [regenerativeness]. I mean, obviously, these folks watching this know stem cells transformed my back. There was a point where I was three, four, five times a year dealing with debilitating back pain. Gosh, it’s been over three years now that I’ve dealt with anything, any attacks.
Dr. Gonzalez:
Wow! That’s awesome.
Dr. Pompa:
I can pick up really heavy things again.
Dr. Gonzalez:
That’s great.
Dr. Pompa:
I just want to live long healthy. If I could maybe ski…
Dr. Gonzalez:
That makes two of us.
Dr. Pompa:
I know. I got to a point where I wasn’t able to ski anymore, and then it went to where I wasn’t able to even push—ride my bike up hills anymore. Then it was to the point where I was waking up stiff at 4 a.m. and just wanting to get out of—okay, that was old age to me. I said no way. I don’t care. I don’t need to drive a fancy car. I don’t have certain values in my life. That is my value, living healthy and being able to do the things I love to do.
Dr. Gonzalez:
Yeah, and start taking care of your bodies.
Dr. Pompa:
For me, it was worth the money, man. That’s the point.
Dr. Gonzalez:
Yeah, that’s great.
Dr. Pompa:
All right, thanks for being here. Appreciate you.
Dr. Gonzalez:
Thank you very much.
Dr. Pompa:
Yeah, absolutely.
Dr. Gonzalez:
Thank you very much for having me.
Dr. Pompa:
The link’s below. Remember, 25% you get because of COVID. I call those COVID blessings, by the way. There’s the COVID curses. That’s a COVID blessing that you all are able to do that, so thank you for doing that too.
Dr. Gonzalez:
Thank you. Thank you very much.
Dr. Pompa:
Take advantage of the free consultation. You get that with the link, and then if you decide you want one of these therapies, then of course you get the 25% off.
Dr. Gonzalez:
Yeah, thank you very much. Thank you.
Dr. Pompa:
Bless you. Thank you.
Dr. Gonzalez:
Thank you. God bless.
Dr. Pompa:
Run to your call. We got to run to your call. I’m going to do—I don’t know if Ashley’s still here. I know she had an appointment.
Ashley:
That’s it for this week. We hope you enjoyed today’s episode. We’ll be back next week and every Friday at 10 a.m. Eastern. We truly appreciate your support. You can always find us at cellularhealing.tv, and please remember to spread the love by liking, subscribing, giving an iTunes review, or sharing the show with anyone who may benefit from the information heard here. As always, thanks for listening.
