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Mold Exposure, Dangerous Chemicals and Toxic Substances: When Toxins Become Lethal

It is common knowledge that we live in a “dirty” world. Dangerous chemicals, toxic substances and mold exposure are everywhere these days.  Because of widespread toxic substances and exposure, there are few places that exist on earth that can boast freedom from dangerous chemicals, toxins and EMF (electric magnetic field) exposure. Where can we go to ensure our safety? Hopefully, we have homes that are toxin, mold and chemical free, and that should be our safe haven. But is that really the case?

On a daily basis, we are exposed to over 6,000 chemicals that we can’t see or smell. Our foods are laced with glyphosate, a virulent chemical that causes leaky gut. Many foods also contain antibiotics, preservatives, colors and additives. Our meats are placed on Styrofoam plates with plastic wrap clinging to the flesh, and of course there is toxic paint, carpet outgassing, EMFs, air fresheners, toxic mold; the list of dangerous chemical and toxic substances goes on and on. In other words, our toxic exposure is enormous.

There are so many potential dangers lurking around the corner. One of the questions I ask during a new client intake is whether they live near a golf course. It seems benign, but the amount of pesticides used on golf course lawns is extremely dangerous and poses a threat to the healthy function of our cells and gut. I am deeply concerned for all those that play golf on a regular basis.Here is a testimony to the dangers of golf course pesticide exposure: “One year, in a tournament near Miami, I had to withdraw after 36 holes. The course had been heavily sprayed, and there was weed killer in the lake. When I got to the course for the third round, I couldn’t hit a wedge shot thirty yards; I didn’t have enough strength. My eyes were bloodshot, my complexion was ruddy, and my right hand was swollen from taking balls from the caddie. My doctor said it was acute pesticide poisoning”. Billy Casper, top US professional golfer

A toxic burden study was funded by the EWG (Environmental Working Group) at Mount Sinai School of Medicine. Bill Moyers, a famous news reporter, recorded the results of this study in his documentary entitled: “Trade Secrets”. Moyers participated in this study along with 8 other adult volunteers. To their knowledge, none of the volunteers had been exposed to high amounts of environmental toxins. However, their blood and urine results were alarming.

The study tested all 9 subjects for 210 harmful and dangerous chemicals. The results: 167 out of the 210 chemicals tested were present in urine and blood samples in varying amounts. In all 9 adults, 91 chemicals were present including: 53 chemicals linked to cancer: 63 of those chemicals are known to be toxic to the CNS (central nervous system): 58 of the chemicals can be damaging to the endocrine system (hypothalamus, pituitary, thyroid and adrenal glands), and 55 chemicals are known to depress the immune system, which can lead to autoimmune conditions.

But the unconscionable chemical and heavy metal exposures to which unsuspecting populations across America are being exposed right now are appalling. The news channels and major publications are buzzing about the poor people in Flint, Michigan, who are being exposed to water that is filled with extremely high levels of lead and other dangerous chemicals.

Unfortunately, their water challenges started back in April of 2014, when the city’s emergency manager switched the drinking water source from Detroit’s system to the Flint River (to save money) and there have been water emergencies ever since.

According to an article in THE NATION, “….First came the three boil-water warnings, which the city issued after finding evidence E. coli and other nasty bacteria in the city’s water supply. These were followed by nine months of dangerously high levels of total trihalomethanes, a carcinogenic byproduct of chlorine, which put the city in violation of the Safe Drinking Water Act; the city had ramped up the chlorine in an effort to kill the E. coli and other gut-busting microbes. Along the way, people have complained about rashes, hair loss, bad smells and worse, leading a group of them to file a lawsuit on June 5 to force the city to stop getting its water from the Flint River. More recently, an internal Environmental Protection Agency memo obtained by the ACLU of Michigan raised concerns about the possibility of widespread lead contamination after the water in one family’s home was found to be contaminated with lead at a level of 13,200 parts per billion (ppb). A lead level of 5,000 ppb is classified as hazardous waste. The EPA memo asserted that the lead issue was the direct result of the cash-strapped city’s inability to handle the job of water treatment.”

In an outrage over the tragedy that is befalling the adults and children of Flint, Michael Moore wrote to his hometown Governor:
“Dear Governor Snyder: Thanks to you, sir, and the premeditated actions of your administrators, you have effectively poisoned, not just some, but apparently ALL of the children in my hometown of Flint, Michigan…..Your staff and others knew that the water in the Flint River was poison — but you decided that taking over the city and “cutting costs” to “balance the budget” was more important than the people's health (not to mention their democratic rights to elect their own leaders). So you cut off the clean, fresh glacial lake water of Lake Huron that the citizens of Flint (including myself) had been drinking for decades and, instead, made them drink water from the industrial cesspool we call the Flint River — a body of “water” where toxins from a dozen General Motors and DuPont factories have been dumped for over a hundred years. And then you decided to put a chemical in this water to “clean” it — which only ended up stripping the lead off of Flint's aging water pipes, placing that lead in the water and sending it straight into people's taps…… Your callous — and reckless….decision to do this has now, as revealed by the city's top medical facility, caused “irreversible brain damage” in Flint's children, not to mention other bodily damage to all of Flint's adults. Here's how bad it is: Even GM won't let the auto parts they use in building cars touch the Flint water because that water “corrodes” them. This is a company that won't even fix an ignition switch after they've discovered it's already killed dozens of people. THAT's how bad the situation is. Even GM thinks you're the devil….”

A MOTHER JONES article states, “According to the World Health Organization, “Lead affects children's brain development resulting in reduced intelligence quotient (IQ), behavioral changes such as shortening of attention span and increased antisocial behavior, and reduced educational attainment. Lead exposure also causes anemia, hypertension, renal impairment, immunotoxicity and toxicity to the reproductive organs. The neurological and behavioral effects of lead are believed to be irreversible.“

Unfortunately, Flint is not the only place that is suffering from over-the-top toxic exposures. In a well-to-do community in Porter Ranch, California, the residents have been exposed to gas leaks that have led the residents to flee their homes. Entire neighborhoods are like ghost towns, where government officials have ordered mandatory clearings of all homes in exposed areas. Residents were forced to leave and seek emergency shelter elsewhere, and most have been displaced for months.

The problem started when methane gas started leaking at extremely high levels. Methane gas can contain mercaptans and other sulfur compounds. According to an article entitled: Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 15. “Methyl mercaptan depresses the central nervous system and affects the respiratory center, similar to hydrogen sulfide, producing death by respiratory paralysis. Clinical signs of exposure are ocular and mucous membrane irritation, headache, dizziness, staggering gait, nausea, and vomiting. Paralysis of the locomotor muscles and pulmonary edema have also been observed.”

But here is an interesting statement in an article written by the LA TIMES: “The sulfur-like compounds it contains, called mercaptans, are not toxic or damaging to the body and do not post long-term risks, public health officials and environmental experts say. It's the odor itself that is causing health problems in the San Fernando Valley community… The additive is a mix of two chemicals, tertiary butyl mercaptan and tetrahydrothiophene, said Glenn La Fevers, storage operations manager for Southern California Gas….. But it (natural gas) also contains small amounts of benzene, toluene and other carcinogens that authorities are testing for in the community. So far, monitors have not found those chemicals at levels any higher than amounts typical in Los Angeles air.”

Now that is spin control! I am not sure why they think the public will buy these ridiculous statements. Methyl mercaptans depress the central nervous system and benzene and toluene are known carcinogens. And that is ok? Does the Gas Company of Southern California really think that people are not going to research these lethal toxins? The beauty of the Internet is that information is as easy to find as a click of a button. No more cover ups please. Don’t insult our intelligence.

The LA TIMES article continues: “Lifelong Porter Ranch resident Dee Ann Abernathy, whose family of six has relocated, said her 6-year-old daughter has experienced several episodes of severe vomiting and has broken out in hives since Nov. 14. Abernathy, 39, bristles at suggestions that fumes emitted by the failed well may not have long-term harmful effects. “My child is not a guinea pig and no one can guarantee that this is not harming her health,” Abernathy said. “I have to wonder whether people who insist there are no long-term effects from this leaking well would continue to do so if it was their daughter vomiting day and night.“

In an article published on saveporterranch.com: Signs and symptoms of methane exposure may include: headaches, heart palpitations, cognitive impairment (poor judgement, memory loss), dizziness, loss of motor coordination and flu-like symptoms (mental uneasiness, lethargy, discomfort)

And the sad stories continue to emerge. As the lead poisoning crisis in Flint, Michigan has resonated across the nation, communities in Pennsylvania are noting high percentages of children with lead. In Altoona, PA over 20 percent of kids under the age of 7 showed elevated levels of lead, according to a Pennsylvania Department of Health report. Elevated lead levels for children under 7 are defined by the Centers for Disease Control as those having at least five micrograms of lead per deciliter of blood in their system. Differing from the Flint crisis, older homes are more likely the source in these cases versus public drinking water. Nathan Sooy of a Pennsylvania office of Clean Water Action noted “In Flint, you’re talking about a major infusion of lead into the water. But that’s not in general how lead poisoning happens in older cities. How it usually happens is from really old houses with lead in the plumbing and old lead paint.” And considering many of the homes in these communities were built before 1940, this data offers a wake-up call to families living in these older homes to examine the major issue of lead poisoning.

So now what? Do these people have to suffer in silence? Are there no ways to resolve these toxic issues? Are the children of Flint Michigan irreversibly brain damaged? Will there be future health disasters as a result of these unbridled methane gas exposures in Porter Ranch? Do families living in old homes have to suffer from lead poisoning?

Over the years, I have listened to horror stories regarding people’s declining health. With tears streaming down their face, they shared a myriad of unrelenting symptoms that doctors can’t explain. There are a cataclysmic amount of folks that are sick and miserable because their cells are drowning in unidentified toxins. Flint, Porter Ranch, and Altoona are not the only communities overrun with chemical exposures. People across America are crying out for help because the root causes of their health challenge is an onslaught of unnoticed or named toxins that are flooding their unprotected cells.

In my case, an unfortunate meeting of two opposing metals in my mouth (mercury silver fillings and gold) poisoned me. This caused me a period of untold agony for 3 years. Other clients have been exposed to countless toxins that have caused autoimmune diseases, cancer and other debilitating health conditions. Did they know these toxins were the start of their bodies undoing? No, but that is why they made their way to me.

Where does one start when toxic exposures are causing horrifying symptoms? Well, the first step to review is my 5R’s of PompaCore Cellular Detox and Healing. I created these 5R’s as a roadmap to heal ailing cells. Remember what I always say: “If you don’t heal the cell, you can’t get well.” So pertinent to this article, R1 is about Removing the Source. In order to protect the healthy functions of the cells, we must remove the source of toxins that are causing widespread inflammation in the cellular membrane.

As the 5R’s of PompaCore Cellular Detox and Healing are addressed, downstream detox pathways (i.e. the gut, liver, kidneys and lymphatic system) must be supported so that toxins can successfully move out of the body. Finally, all my trained doctors use a product called CytoDetox™, a true binding agent, to safely draw out heavy metals from the tissue, organs, bones and brain. Then we capture those metals and clear them out of the body with BIND super activated charcoal (Note: lead gets stored in the bone, so we need to follow a protocol that is safe and effective to ease it out naturally). There is a very precise way to rid the body of heavy metals called PompaCore Cellular Detox™, and you can learn the three components and three phases of the process here. Please read the article and contact my office for more information on working with one of my trained practitioners who can support you through the process (call 800.833.2941 or contact me here).

Now, the lead levels in the Flint water are at a lethal amount and of course, folks get panicked. This is totally understandable. But is the damage really irreversible? I don’t think so. I have seen many remarkable recoveries over the years when toxic stressors have been removed. And there are ways to remove these metals from the body and brain. So, to the people of Flint Michigan, please read my article series on safe heavy metal removal (Part 1, Part 2 and Part 3) and don’t lose hope.

After my body started to heal, I decided to test my wife and children to see if they had elevated heavy metals. My wife’s lead levels were through the roof. In fact, they were so dangerously high that the lab wanted her to repeat the test! Then we found out that my sons also had extremely high lead levels. So I hunkered down, made sure they were eating a Cellular Healing Diet to decrease inflammation and I started them on an ON and OFF cyclical heavy metal protocol to reduce their lead levels. I supported their methylation levels (methylation helps the body reduce inflammation and detox) with a product by Systemic Formulas called MoRS. And I supported their mitochondria (the powerhouse of the cell that makes ATP energy) with a product called eNRG. Lo and behold, over time, their metals levels started to go down. This is part of PompaCore Cellular Detox™ I am convinced it saved the lives of my wife and my children.

As for the folks in Porter Ranch, Altoona, and the countless other areas in the country affected by heavy metal poisoning, my advice is to also follow my system of PompaCore Cellular Detox™ as noted above and outlined here. Short fasts and intermittent fasting will further enable your body to gobble up any lingering toxin debris. These fasts can be extremely healing to the body in addition to PompaCore Cellular Detox™. It is safe and easy to do, and you can follow my instructions in the article. I would also include CytoDetox™, BIND, MoRS and eNRG cellular products to start the healing process, and I add Vista 1 and 2 containing good fats to increase healing of the cellular membranes.

There is one thing I know: the body is an extraordinary healing machine, and it was designed by God to regain optimal health. There is no hopeless situation when it comes to the regenerative capabilities of our cells. What we need to do is educate ourselves on the step-by-step process that can lead to renewed health. I wish you the best and let us know if we can support your detoxification or community.

The Three-Legged Stool: The Autoimmune Answer

The Three-Legged Stool: Autoimmunity occurs when the body’s immune system attacks itself, and despite the rise in autoimmune conditions, there is no single solution to cure the symptoms.

Autoimmunity is the label given to a cluster of unexplained symptoms, including eczema, celiac disease, type 1 and 2 diabetes, Hashimoto’s, leaky gut, lupus, and IBS. Today we explore a concept known as the three-legged stool to tackle autoimmunity from a functional medicine perspective.

The Three-Legged Stool: What is the Immune System?

The immune system is an extensive network of cells and proteins that defends the body against infection. The immune system keeps a record of every foreign invader (called antigens) it has ever attacked so that it can recognize and destroy the microbe faster if it enters the body again 1.

Key players of the immune system include white blood cells, antibodies, the complement system, the lymphatic system, the spleen, the thymus, and the bone marrow. Although these are the parts of the body that actively fight infection, the whole body always plays a role, less directly.

What is Autoimmune Disease?

Autoimmune disease is diagnosed when the body’s immune system attacks healthy cells. In reality, this “disease” is not a proper diagnosis and is simply the blanket term given to an illness to which the root cause is not understood 2.

Some examples of autoimmune diseases include: 2-3

  • Rheumatoid arthritis

  • Lupus

  • Celiac disease

  • Sjögren’s syndrome

  • Multiple sclerosis (MS)

  • Type 1 diabetes

  • Inflammatory bowel disease (IBD)

  • Guillain-Barre syndrome

  • Psoriasis

  • Grave’s disease

  • Hashimoto’s thyroiditis

The Three-Legged Stool: Common Autoimmune Symptoms

You may be reading so far and think that “this article is not for me… I don’t have an autoimmune disease.” Still, the reality is that autoimmunity can’t be specifically tested for, and the long list of diseases that fall under the category of autoimmunity are not proper diagnoses.

Suppose you know something is out of whack with your body. In that case, the collection of symptoms you’re experiencing may be autoimmunity, even if they don’t fall under one of the classic labeled types.

Common symptoms of autoimmunity include: 4-5

  • Headaches

  • Anxiety

  • Brain fog

  • Dry mouth

  • Swollen glands

  • Attention-deficit problems

  • Body rashes

  • Acne

  • Eczema

  • Psoriasis

  • Rosacea

  • Dermatitis

  • Allergies

  • Asthma

  • Frequent colds

  • Underactive or overactive thyroid problems, including Hashimoto’s disease or Graves disease

  • Fatigue or hyperactivity

  • Feeling “wired and tired.”

  • Weight gain or loss

  • A general feeling of unease

  • Muscle pain and weakness

  • Stiffness and pain, including rheumatoid arthritis or fibromyalgia symptoms

  • Exhaustion

  • Digestive tract upset including irritable bowel disease (IBS) or Crohn’s disease

  • Abdominal pain

  • Stomach cramping

  • Gas

  • Bloated stomach

  • Diarrhea

  • Constipation

Autoimmunity is not that helpful of a diagnosis because it is not uncovering a root cause. It is simply the collection of unexplained symptoms that cause the body to attack itself 5. Often, we dismiss such a type of diagnosis by suggesting that it’s a normal reaction to life.

Terms like “mommy brain,” “that time of the month,” or simply “getting old” dismiss the very real symptoms that are diminishing your quality of life. Before ignoring your symptoms merely because they are common, best understand how the three-legged stool analogy may bring you back to thriving.

The Three-Legged Stool: The Autoimmune Answer

People are getting sick and not getting well; what is going on? The three-legged stool analogy addresses the “why” behind the explosion of autoimmune diagnoses we have coming out of the West.

Although humans generally want there to be one answer to their question, the reality is that autoimmune illness is complex. Western medicine has primed our brains to seek one pill, one shot, or one operation to ‘fix’ the problem, but as we can see by the booming and unsolved autoimmune diagnosis, this one problem one solution mindset just does not work.

The concept itself is straightforward: for a stool to function, all three legs have to be present. Take one (or more) away, and the chair falls. Like a stool, your body has three main pillars that must be supported for you to experience good health, they are:

  1. Stressors (Physical, Chemical, and Emotional)

  2. Gut/ Microbiome

  3. DNA

Stressors

Stress comes in three forms: chemical, emotional, and physical. Every drop of stress builds up in the body until the metaphorical bucket begins to overflow 6-8. This overflow s why some people hit a wall out of “nowhere”: your stress bucket has been accumulating for years. So the final event that tipped the scale might not have seemed like anything major, but in fact, it’s the cumulative effect of stress over a lifetime.

Chemical stressors are found everywhere in our modern environments. They include toxins found in 6-10

  • Food (GMOs, pesticides, herbicides, processed foods)

  • Mercury in amalgam fillings

  • Heavy metal toxicity (industrial exposure, air or water pollution, foods, medicines, improperly coated food containers, or lead-based paints)

  • Black mold found in homes, schools, stores, and office buildings

  • Tap water toxins (including chlorine and fluoride)

  • Conventional body care products (including SLS, parabens, and fragrances)

Physical stressors are also common-place in modern life. They include:

  • Too little or too much exercise

  • Stagnancy (sitting or standing in one position all day long)

  • Unaddressed biomechanical imbalances

  • Wearing conventional shoes (too narrow, or with a heel)

Emotional stressors are perhaps the least acknowledged form of stress because they are perceived stress. Perceived stress from negative emotions has just a real impact on stress hormones in the body. Although all emotions are healthy and normal, emotional stress is when stress becomes chronic and a looping feeling, without any resolution. These emotions include: 11

  • Grief

  • Sadness

  • Anger

  • Frustration

  • Anxiety

  • Depression

Gut/ Microbiome

Dysbiosis in any of the body’s microbiomes (like the gut, oral, and skin) is associated with chronic inflammation in the body 12. The gut is significant when it comes to autoimmunity since it plays such a large role in regulating the immune system 13. Changes in the gut microbiome (too much, too little, or an imbalance of the “good” to “bad” bacteria) can cause immune dysregulation, which can lead to autoimmune disorders 14.

DNA

The old paradigm of disease often blamed genetics for our illnesses. Whatever runs in the family was understood to be inevitable when that simply is not the case. The newer branch of epigenetic science understands that although genes are present, they act as a loaded gun. Having a gene that predisposes you to cancer, diabetes, or Alzheimer’s makes it more likely to develop a disease but does not actually pull the trigger 15.

What pulls the trigger is lifestyle choices 15—particularly the two legs of the stool mentioned above: stress and gut/ microbiome. When stress or the gut microbiome is out of balance, this can trigger a genetic trait to turn on.

With all the incredible genetic testing available, we can get very informed about the pre-dispositions that our DNA holds, but it’s important not to let that scare you. The awareness of these pre-dispositions can cause more mental stress than benefit.

Rather than assuming an APOE-e4 gene (for example) will pretty much guarantee you develop Alzheimer’s, or that the BRCA1 or 2 genes will give you breast cancer 16— better to use this information as a reminder—your healthy lifestyle choices are more important than ever.

Getting Your Life Back: A Multi-Therapeutic Approach to Autoimmune Disease

You can understand autoimmunity as the perfect storm of stressors, as generally all three of these stool legs have been lost by the time you have an autoimmune diagnosis.

By understanding the source of the imbalance, we can then tackle autoimmunity with a multi-therapeutic approach to support or re-build these pillars (legs of the stool) so that you can get your life back. Knowing the cause also gives us the solution.

One of the most common missing links while addressing autoimmune disease healing is the chemical or toxic stressors on the body. Although the concept of detox is well known to most, an appropriate approach is not. Quick fixes, store-bought detox teas, or foot baths fail to safely and effectively target the cellular source of toxins.

The 5R Approach

The 5R approach to detox targets toxicity all the way upstream to the source: the cell. Cellular detox is not a quick fix, and although many symptoms can and often do alleviate within the first few months, it’s essential to stick with the protocols for much longer to undo years of toxic build-up.

The 5R approach entails:

  1. Removing the Source

  2. Regenerating the Cell Membrane

  3. Restoring Cellular Energy

  4. Reducing Inflammation

  5. Reestablishing Methylation

If you are dealing with chronic issues of autoimmunity, the best way to navigate a 5R healing approach is under the care of a functional medicine practitioner. This is why thousands of doctors across America are trained in this method to support a safe and effective journey out of chronic illness and back to health. You can connect with a practitioner by calling (800) 833-2941.

Ancient Healing Techniques

Alongside the 5R approach to safe and effective detoxification, ancient healing techniques are used to harness the power of hormesis. Hormetic stress generates hormesis, a positive adaptation in the body. This strengthens the bodily systems to be more flexible and resilient against changes in the environment 17.

Some examples of hormetic stressors include:

  • Dietary adaptation (some ketogenic low carb days, some high carb days, some fasting days)

  • Intermittent fasting (periods of feeding and periods of fasting, within a 24-hour cycle)

  • Feast/ famine cycling (periods of extended fasting)

  • Hot/ cold therapy

  • Exercise (some explosive training days, some slow heavy training days, some recovery days)

It’s important to understand that although hormetic stress is “good” stress, it is still stress. If you are dealing with debilitating autoimmune symptoms, hormetic stressors need to be introduced very gently.

Some ways to ease into hormetic stressors:

  • Dietary adaptation would involve more high carb days, as you slowly become more metabolically flexible, you can introduce more low carb and fasting days.

  • Intermittent fasting could hover around 12 hours of feeding and 12 hours of fasting per day. This fasting can increase slowly with time, as the body can handle it.

  • Longer fasting periods can be introduced once metabolic flexibility is increased through dietary adaptation and intermittent fasting and under the care of a practitioner.

  • Instead of taking an ice bath right off the bat, you can take a quick cold shower at the end of a hot shower. You can even start off by simply doing a cold face plunge in a big bowl with a few ice cubes.

  • Exercise for shorter periods regularly, and increase intensity over time. For someone who is very sick, stick to relaxing forms of movement like gentle walks or yoga, knowing that as the body heals, you will introduce more intense forms of exercise.

Summary

Autoimmune diseases are on the rise, and diagnoses include various illnesses where the immune system attacks itself. However, the diagnosis itself to autoimmunity does not address the root cause because the diagnosis is based on symptoms. One way to understand, and therefore start to heal from, autoimmunity is the three-legged stool analogy.

Stress, the gut/ microbiome, and DNA form the three legs of the stool, and autoimmunity becomes an issue when one or more (but generally all three) are off. The perfect storm that creates autoimmunity can countered with a multi-therapeutic approach that uses the 5R method for detox and ancestral healing techniques.

Medical Disclaimer: This article is based upon the opinions of Dr. Daniel Pompa. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Pompa and his associates. This article has been medically reviewed by Dr. Charles Penick, MD for accuracy of the information provided, but Dr. Pompa encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional.

References

1 Jerne, Niels Kaj. “THE IMMUNE SYSTEM.” Scientific American, vol. 229, no. 1, 1973, pp. 52–63., www.jstor.org/stable/24923147. Accessed 29 Apr. 2021.

2 Marrack, P., Kappler, J. & Kotzin, B. Autoimmune disease: why and where it occurs. Nat Med 7, 899–905 (2001). https://doi.org/10.1038/90935

3 “Autoimmune Diseases: What Are They? Who Gets Them?” WebMD, WebMD, www.webmd.com/a-to-z-guides/autoimmune-diseases.

4 Zerbe, Leah. “If You Have These Symptoms, You May Have an Autoimmune Disease.” Dr. Axe, 16 Dec. 2019, draxe.com/health/autoimmune-disease-symptoms/.

5 “What Are Common Symptoms of Autoimmune Disease?” Johns Hopkins Medicine, www.hopkinsmedicine.org/health/wellness-and-prevention/what-are-common-symptoms-of-autoimmune-disease.

6 Cox, Paul Alan, et al. “Dietary Exposure to an Environmental Toxin Triggers Neurofibrillary Tangles and Amyloid Deposits in the Brain.” Proceedings of the Royal Society B: Biological Sciences, vol. 283, no. 1823, 2016, p. 20152397., doi:10.1098/rspb.2015.2397.

7 Wani, Ab Latif et al. “Lead toxicity: a review.” Interdisciplinary toxicology vol. 8,2 (2015): 55-64. doi:10.1515/intox-2015-0009

8 Mueller, Thomas C., et al. “Shikimate Accumulates in Both Glyphosate-Sensitive and Glyphosate-Resistant Horseweed (Conyza CanadensisL. Cronq.).” Journal of Agricultural and Food Chemistry, vol. 51, no. 3, 2003, pp. 680–684., doi:10.1021/jf026006k.

9 Progovitz, Richard F. Black Mold: Your Health and Your Home. Forager Press, 2003.

10 “What Are Parabens, and Why Don’t They Belong in Cosmetics?” Environmental Working Group, www.ewg.org/what-are-parabens.

11 Campbell, Jana, and Ulrike Ehlert. “Acute Psychosocial Stress: Does the Emotional Stress Response Correspond with Physiological Responses?” Psychoneuroendocrinology, vol. 37, no. 8, 2012, pp. 1111–1134., doi:10.1016/j.psyneuen.2011.12.010.

12 Dehner C, Fine R, Kriegel MA. The microbiome in systemic autoimmune disease: mechanistic insights from recent studies. Curr Opin Rheumatol. (2019) 31:201–7. doi: 10.1097/BOR.0000000000000574

13 Chung, Hachung, and Dennis Lee Kasper. “Microbiota-stimulated immune mechanisms to maintain gut homeostasis.” Current opinion in immunology vol. 22,4 (2010): 455-60. doi:10.1016/j.coi.2010.06.008

14 Wu, Hsin-Jung, and Eric Wu. “The role of gut microbiota in immune homeostasis and autoimmunity.” Gut microbes vol. 3,1 (2012): 4-14. doi:10.4161/gmic.19320

15 “What Is Epigenetics?” Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, 3 Aug. 2020, www.cdc.gov/genomics/disease/epigenetics.htm.

16 Scacheri, Cheryl. “Genetic Variation and Disease: GWAS.” Nature News, Nature Publishing Group, www.nature.com/scitable/topicpage/genetic-variation-and-disease-gwas-682/.

17 Mattson, Mark P. “Hormesis defined.” Ageing research reviews vol. 7,1 (2008): 1-7. doi:10.1016/j.arr.2007.08.007

R5 Reestablishing Methylation Turning Genes On/Off and Gene Expression

R5 – Reestablishing Methylation

Methylation is a process that plays a crucial role in gene regulation and the maintenance of cellular function. It involves adding a methyl group (-CH3) to DNA, which alters the expression of genes without changing their underlying sequence. This process is essential for normal development and plays a critical role in gene expression, genomic stability, and cellular differentiation. However, alterations in DNA methylation patterns have been linked to various diseases.1

Depletion Of Methyl Groups

The depletion of the methyl groups available for methylation have a number of negative effects on our health. Methylation helps to control inflammation in the body. When there is a lack of methyl groups, this leads to an increase in pro-inflammatory markers and chronic inflammation.2

Methylation also plays a role in regulating our immune system. Chronic stress-induced depletion of methyl groups weaken our immune response, making us more vulnerable to illness and disease.3

Methylation is involved in various biochemical reactions that are necessary for energy production. Methylation is important for proper brain function, including controlling neurotransmitter levels and supporting the growth of new neurons. Chronic stress-induced depletion of methyl groups lead to changes in brain structure and function, contributing to mood disorders such as depression and anxiety.4

Reestablishing Methylation - Toxic Estrogen Metabolites

Reestablishing Methylation – Toxic Estrogen Metabolites

One important aspect of methylation is its ability to modify toxic hormones such as estrogen metabolites. Estrogen is an essential hormone responsible for regulating female reproductive functions and secondary sexual characteristics. However, some metabolic byproducts of estrogen are harmful to the body if not properly eliminated.

Methylation helps convert these toxic estrogen metabolites into less toxic forms that can easily be flushed out of the body. This process protects our cells from DNA damage and reduces the risk of developing hormone-related diseases.5

In addition to detoxifying hormones, methylation also aids in the breakdown and elimination of other toxic substances from our body. This includes environmental toxins, heavy metals, and certain medications.6

Methylation And Heavy Metals

Methylation is a critical process for detoxifying heavy metals from the body. When heavy metals enter the body, they disrupt normal cellular functions and cause damage to tissues and organs. To counteract their harmful effects, our bodies use methylation to convert these metals into less toxic forms that can be easily eliminated through urine.7

In addition to detoxification, methylation also plays a role in protecting against heavy metal toxicity. Methylation helps regulate the expression of genes that are involved in antioxidant defense and repair mechanisms. This is important because heavy metals cause oxidative stress, which damage cells and lead to chronic diseases.8

However, excessive exposure to heavy metals overwhelms the body's methylation capacity, leading to a buildup of toxic forms of these metals. This results in various health problems, including neurological disorders, kidney damage, and developmental delays in children.9

Read more about R1 – Removing The Source Of Toxicity to avoid heavy metal exposure.

Methylation And Genetic Expression

One of the most significant effects of decreased methylation is the activation of “bad” genes. These are genes that should normally be turned off, but due to the lack of methylation, they become active. This leads to the production of abnormal proteins or disruption of important cellular processes.10

Aside from its role in gene regulation, methylation also plays a crucial role in maintaining genomic stability. It helps to protect DNA from damage and prevents errors during DNA replication. When methylation levels are low, there is an increased risk of mutations and genomic instability, which leads to the development of various diseases.11

Reestablishing Methylation

Reestablishing Methylation – Fat Agouti Gene

One gene that has been extensively studied in relation to methylation is the Agouti gene. This gene is linked to body weight by regulating the production of a signaling molecule called Agouti. However, when this gene is overexpressed, it leads to obesity.

Interestingly, scientists have discovered that the expression of this gene is heavily influenced by environmental factors such as exposure to the toxin BPA. Specifically, exposure to BPA during pregnancy results in epigenetic changes to the gene, leading to its overexpression and adverse health effects in offspring.12

This discovery sparked interest in the possibility of reestablishing methylation patterns on the gene to reverse its negative effects. Researchers have conducted various experiments using dietary supplements, such as folic acid and betaine, which are known to be involved in the methylation process. Interestingly, these studies have shown promising results in reducing the expression of the gene and improving the health of offspring.13

The Connection Between Methylation And Glutathione

Methylation and glutathione are two closely related processes in the human body. Glutathione is an antioxidant that helps protect cells from damage caused by free radicals that we discussed in R3 – Restoring Cellular Energy.

Both methylation and glutathione play important roles in maintaining our overall health. In fact, the two processes are closely intertwined and can have a significant impact on each other. People with methylation issues often have lower levels of glutathione due to impaired methylation pathways.14

One of the key ways that methylation and glutathione are connected is through their role in detoxification. Methylation helps to convert harmful toxins into less harmful substances that can then be eliminated from the body. Glutathione, on the other hand, plays a crucial role in neutralizing and removing toxins from the body. As such, a decrease in either methylation or glutathione levels leads to a buildup of toxins, which have negative effects on our health.15

In addition to their role in detoxification, both processes also play important roles in maintaining proper immune function. Methylation is involved in regulating gene expression and supporting the production of white blood cells, which are vital for fighting off infections and diseases. Glutathione helps to protect immune cells from damage caused by free radicals, allowing them to function effectively.16

Furthermore, both methylation and glutathione have been linked to various health conditions. For example, deficiencies in either process have been associated with autoimmune disorders, cardiovascular disease, and neurological disorders. Additionally, research has shown that certain lifestyle factors, such as stress and poor nutrition, impact both methylation and glutathione levels.17

Homozygous MTHFR Gene And Methylation

One key player in this process of methylation is the MTHFR gene, which codes for an enzyme involved in converting homocysteine to methionine. Variations in the MTHFR gene have been linked to various health conditions, leading to many people undergoing genetic testing to see if they carry these variations.18

Despite the hype surrounding the MTHFR gene, researchers now believe that it may not be as crucial as previously thought. Studies have shown that while certain variations in the gene can affect enzyme function and lead to elevated homocysteine levels, these variations do not significantly impact overall health.19

Instead, the most critical factor in methylation is not the MTHFR gene itself but rather the availability of key nutrients and cofactors needed for proper enzyme function. These include vitamins B2, B6, and B12, folate, choline, and betaine, among others.20

Additionally, lifestyle factors such as diet and stress also play a significant role in methylation. A poor diet lacking in essential nutrients or high levels of stress can disrupt the methylation process and lead to health issues.21

Therefore, instead of solely focusing on the MTHFR gene, it is vital to pay attention to overall methylation status and ensure that the body has all the necessary nutrients for proper function. This can be achieved through a balanced and nutritious diet along with stress management techniques.

Read more about my Cellular Healing Diet that plays a core role in the 5Rs.

Methylation And The Microbiome

Recent studies have shown a close connection between methylation and the microbiome. The microbiome plays a crucial role in regulating methylation patterns in our body. This is because the microbiome produces various metabolites that directly or indirectly affect methylation. For example, short-chain fatty acids (SCFAs) produced by gut bacteria have been found to regulate gene expression through DNA methylation.22

Furthermore, alterations in the microbiome composition have been linked to changes in methylation patterns. Dysbiosis, which is an imbalance in the gut microbiome, has been associated with various health conditions such as inflammatory bowel disease, metabolic disorders, and even mental health disorders. These conditions have also been linked to changes in methylation patterns.23

Studies have also shown that the microbiome affect methylation in other parts of the body besides the gut. For instance, a study found that periodontal bacteria can influence DNA methylation in the oral cavity. This highlights the importance of considering the microbiome when studying methylation patterns.24

Reestablishing Methylation - Microbiome

Reestablishing Methylation – Reducing Stressors

Stressors, whether they are physical, chemical, or emotional, have a significant impact on our overall health and well-being. The human body is designed to respond to stress through various mechanisms such as the release of hormones like cortisol and adrenaline. These responses are part of our innate fight-or-flight response, designed to help us cope with potential threats. However, when stress becomes chronic or overwhelming, it can have detrimental effects on our physical and mental health.

One of the ways that stress impacts our body is through changes in DNA methylation. Studies have found that individuals who are exposed to chronic stress or trauma tend to have lower levels of DNA methylation. This leads to changes in gene expression, and increases the risk for various health conditions such as cardiovascular disease, autoimmune conditions, and mental health disorders.25

Moreover, research has also linked exposure to environmental toxins and pollutants to changes in DNA methylation. Chemical stressors such as air pollution, pesticides, and heavy metals have been shown to alter DNA methylation patterns, potentially increasing the risk for various health issues.26 27

R5 – Reestablishing Methylation

To support healthy methylation, it is important to maintain a balanced diet rich in nutrients such as B vitamins, folate, magnesium, and antioxidants. Regular exercise and stress management techniques also help to promote optimal methylation.

You made it! That completes the 5Rs of achieving ideal health.

For review, read about any of the 5Rs again. R4 – Reducing Cellular Inflammation, R3 – Restoring Cellular Energy, R2 – Regenerating The Cellular Membrane, and R1 – Removing The Source Of Toxins.

Take the next step to achieving true health and save a seat in my upcoming free training seminar.

References

1 Gouil Q, Keniry A. Latest techniques to study DNA methylation. Essays Biochem. 2019 Dec 20;63(6):639-648. doi: 10.1042/EBC20190027. PMID: 31755932; PMCID: PMC6923321.

2 Bayarsaihan D. Epigenetic mechanisms in inflammation. J Dent Res. 2011 Jan;90(1):9-17. doi: 10.1177/0022034510378683. PMID: 21178119; PMCID: PMC3144097.

3 Calle-Fabregat C, Morante-Palacios O, Ballestar E. Understanding the Relevance of DNA Methylation Changes in Immune Differentiation and Disease. Genes (Basel). 2020 Jan 18;11(1):110. doi: 10.3390/genes11010110. PMID: 31963661; PMCID: PMC7017047.

4 Li M, D'Arcy C, Li X, Zhang T, Joober R, Meng X. What do DNA methylation studies tell us about depression? A systematic review. Transl Psychiatry. 2019 Feb 4;9(1):68. doi: 10.1038/s41398-019-0412-y. PMID: 30718449; PMCID: PMC6362194.

5 Almeida M, Soares M, Fonseca-Moutinho J, Ramalhinho AC, Breitenfeld L. Influence of Estrogenic Metabolic Pathway Genes Polymorphisms on Postmenopausal Breast Cancer Risk. Pharmaceuticals (Basel). 2021 Jan 27;14(2):94. doi: 10.3390/ph14020094. PMID: 33513690; PMCID: PMC7910923.

6 Waly M, Olteanu H, Banerjee R, Choi SW, Mason JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky VA, Deth RC. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psychiatry. 2004 Apr;9(4):358-70. doi: 10.1038/sj.mp.4001476. PMID: 14745455.

7 Elkin ER, Higgins C, Aung MT, Bakulski KM. Metals Exposures and DNA Methylation: Current Evidence and Future Directions. Curr Environ Health Rep. 2022 Dec;9(4):673-696. doi: 10.1007/s40572-022-00382-4. Epub 2022 Oct 25. PMID: 36282474; PMCID: PMC10082670.

8 Freydenzon A, Nabais MF, Lin T, Williams KL, Wallace L, Henders AK, Blair IP, Wray NR, Pamphlett R, McRae AF. Association between DNA methylation variability and self-reported exposure to heavy metals. Sci Rep. 2022 Jun 22;12(1):10582. doi: 10.1038/s41598-022-13892-w. PMID: 35732753; PMCID: PMC9217962.

9 Vaiserman A, Lushchak O. DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence. Environ Epigenet. 2021 Oct 6;7(1):dvab007. doi: 10.1093/eep/dvab007. PMID: 34631153; PMCID: PMC8493661.

10 Kandi V, Vadakedath S. Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review. Cureus. 2015 Aug 24;7(8):e309. doi: 10.7759/cureus.309. PMID: 26430583; PMCID: PMC4582005.

11 Sriraman A, Debnath TK, Xhemalce B, Miller KM. Making it or breaking it: DNA methylation and genome integrity. Essays Biochem. 2020 Oct 26;64(5):687-703. doi: 10.1042/EBC20200009. PMID: 32808652; PMCID: PMC7606623.

12 Dolinoy DC. The agouti mouse model: an epigenetic biosensor for nutritional and environmental alterations on the fetal epigenome. Nutr Rev. 2008 Aug;66 Suppl 1(Suppl 1):S7-11. doi: 10.1111/j.1753-4887.2008.00056.x. PMID: 18673496; PMCID: PMC2822875.

13 Kadayifci FZ, Zheng S, Pan YX. Molecular Mechanisms Underlying the Link between Diet and DNA Methylation. Int J Mol Sci. 2018 Dec 14;19(12):4055. doi: 10.3390/ijms19124055. PMID: 30558203; PMCID: PMC6320837.

14 Menezo Y, Clement P, Clement A, Elder K. Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life. Int J Mol Sci. 2020 Dec 7;21(23):9311. doi: 10.3390/ijms21239311. PMID: 33297303; PMCID: PMC7730869.

15 Gasmi A, Noor S, Piscopo S, Menzel A. Toxic Metal -Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants. Arch Razi Inst. 2022 Apr 30;77(2):525-536. doi: 10.22092/ARI.2021.356279.1816. PMID: 36284949; PMCID: PMC9548276.

16 Ferreira AV, Koeken VACM, Matzaraki V, Kostidis S, Alarcon-Barrera JC, de Bree LCJ, Moorlag SJCFM, Mourits VP, Novakovic B, Giera MA, Netea MG, Domínguez-Andrés J. Glutathione Metabolism Contributes to the Induction of Trained Immunity. Cells. 2021 Apr 21;10(5):971. doi: 10.3390/cells10050971. PMID: 33919212; PMCID: PMC8143087.

17 Jin Z, Liu Y. DNA methylation in human diseases. Genes Dis. 2018 Jan 31;5(1):1-8. doi: 10.1016/j.gendis.2018.01.002. PMID: 30258928; PMCID: PMC6147084.

18 Leclerc D, Sibani S, Rozen R. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013. Available from: https://www.ncbi.nlm.nih.gov/books/NBK6561/

19 Dean L. Methylenetetrahydrofolate Reductase Deficiency. 2012 Mar 8 [Updated 2016 Oct 27]. In: Pratt VM, Scott SA, Pirmohamed M, et al., editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK66131/

20 Raghubeer S, Matsha TE. Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks. Nutrients. 2021 Dec 20;13(12):4562. doi: 10.3390/nu13124562. PMID: 34960114; PMCID: PMC8703276.

21 Barati S, Fabrizio C, Strafella C, Cascella R, Caputo V, Megalizzi D, Peconi C, Mela J, Colantoni L, Caltagirone C, Termine A, Giardina E. Relationship between Nutrition, Lifestyle, and Neurodegenerative Disease: Lessons from ADH1B, CYP1A2 and MTHFR. Genes (Basel). 2022 Aug 22;13(8):1498. doi: 10.3390/genes13081498. PMID: 36011409; PMCID: PMC9408177.

22 Guo W, Zhang Z, Li L, Liang X, Wu Y, Wang X, Ma H, Cheng J, Zhang A, Tang P, Wang CZ, Wan JY, Yao H, Yuan CS. Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes. Pharmacol Res. 2022 Aug;182:106355. doi: 10.1016/j.phrs.2022.106355. Epub 2022 Jul 14. PMID: 35842183.

23 Srivastava S, Singh A, Sandeep K, Yadav D. Epigenetic Regulation of Gut Microbial Dysbiosis. Indian J Microbiol. 2021 Jun;61(2):125-129. doi: 10.1007/s12088-021-00920-y. Epub 2021 Feb 11. PMID: 33612870; PMCID: PMC7877904.

24 Zhao Z, Wang H, Li X, Hou J, Yang Y, Li H. Comprehensive analysis of DNA methylation for periodontitis. Int J Implant Dent. 2022 May 2;8(1):22. doi: 10.1186/s40729-022-00420-8. PMID: 35491409; PMCID: PMC9058047.

25 Vinkers CH, Kalafateli AL, Rutten BP, Kas MJ, Kaminsky Z, Turner JD, Boks MP. Traumatic stress and human DNA methylation: a critical review. Epigenomics. 2015;7(4):593-608. doi: 10.2217/epi.15.11. PMID: 26111031.

26 Rider CF, Carlsten C. Air pollution and DNA methylation: effects of exposure in humans. Clin Epigenetics. 2019 Sep 3;11(1):131. doi: 10.1186/s13148-019-0713-2. PMID: 31481107; PMCID: PMC6724236.

27 Giambò F, Leone GM, Gattuso G, Rizzo R, Cosentino A, Cinà D, Teodoro M, Costa C, Tsatsakis A, Fenga C, Falzone L. Genetic and Epigenetic Alterations Induced by Pesticide Exposure: Integrated Analysis of Gene Expression, microRNA Expression, and DNA Methylation Datasets. Int J Environ Res Public Health. 2021 Aug 17;18(16):8697. doi: 10.3390/ijerph18168697. PMID: 34444445; PMCID: PMC8394939.

R3 Restoring Cellular Energy ATP Acceleration and Mitochondria Support

R3 – Restoring Cellular Energy

Restoring cellular energy is essential for optimal bodily function. Without enough energy, our cells cannot carry out their necessary functions like cellular detoxification. If allowed to build up, toxins disrupt cellular energy production, leading to fatigue, decreased cognitive function, thyroid problems, and other health problems.

Mitochondria – The Powerhouse Of The Cell

Mitochondria are often referred to as the powerhouse of the cell, and for good reason. These tiny organelles are responsible for producing adenosine triphosphate (ATP), which is the primary source of energy for cellular processes. Aside from being involved in energy production, mitochondria also play a crucial role in detoxification and epigenetic expression.1

Mitochondria ATP Production And Glutathione Detox The Cell

Glutathione is an essential antioxidant that plays a crucial role in maintaining our overall health. It is often referred to as the “master antioxidant” due to its ability to protect cells from damage caused by free radicals and toxins. It also plays a crucial role in detoxifying harmful substances within the cell.2

Glutathione requires a significant amount of ATP for its production. If we aren’t producing enough ATP, the production of glutathione will also decrease, leading to an imbalance in oxidative stress.3

When there is not enough glutathione to detoxify the cell, toxins and free radicals accumulate and cause damage. This damage leads to inflammation, which triggers the expression of harmful genes. Therefore, maintaining adequate levels of glutathione is crucial for preventing oxidative stress and minimizing the risk of various health conditions.4

Mitochondria – Detox And Epigenetic Expression

Mitochondria have a unique ability to store calcium ions, which are crucial for signaling processes involved in the detoxification of harmful molecules. They also contain enzymes that help break down toxins and other harmful substances.5

In addition to detoxification, mitochondria also have an impact on epigenetic expression. Epigenetics refers to changes in gene expression that do not involve alterations in the DNA sequence. These changes are influenced by various factors, including environmental conditions and lifestyle choices. Mitochondria contribute to this process by releasing signaling molecules that influences the activity of certain genes.6

One such signaling molecule is hydrogen peroxide, which is produced as a byproduct of ATP production. When released from mitochondria, it acts as a messenger to activate specific proteins involved in epigenetic regulation. Additionally, mitochondria also contain their own DNA, known as mitochondrial DNA (mtDNA), which has been shown to play a role in regulating gene expression.7 8

Interestingly, recent research has shown that alterations in mitochondrial function and mtDNA leads to changes in epigenetic patterns, contributing to the development of certain diseases. One of the main consequences of decreased mitochondrial ATP production is the activation of bad genes. These genes are usually turned off in young and healthy individuals but become activated when mitochondria fail to produce enough energy.9

In order to prevent this from happening, it is important to maintain healthy mitochondrial function. This can be achieved through a balanced diet, regular exercise, and avoiding harmful environmental factors such as pollution and toxins.

Restoring Cellular Energy - Mitochondria - Detox And Epigenetic Expression

Blood Hormone Levels Don’t Indicate How Well Hormones Function

The level of hormones in our blood is often used as an indicator of hormonal balance. However, it is important to note that what truly matters is not the blood levels of hormones, but rather, how they attach to receptors and relay messages into cells.10

The process of hormone-receptor binding is highly specific and each hormone can only bind to its corresponding receptor. This precise interaction ensures that the right message is delivered to the right cell at the right time, avoiding any potential errors or confusion.

The number and sensitivity of receptors also play a crucial role in hormone signaling. If there are not enough receptors or if they are less sensitive, the message may not be relayed effectively, leading to hormonal imbalances.11

Additionally, hormones have different effects depending on the target cell's type and location. For example, thyroid hormones may stimulate metabolism in one tissue, while promoting growth and development in another.12

Furthermore, hormonal signaling is not a one-way process, as it involves communication between the hormone-secreting gland and its target organs or feedback loops to maintain homeostasis.13

Cellular Energy And Hormone Dysfunction

When our cellular energy levels are low, it can lead to problems with hormone production and transportation. This means that even if our body is producing adequate amounts of hormones, they may not be able to properly attach to their receptors on cells and carry out their functions effectively.

Studies have shown that chronic inflammation interferes with hormone receptor function. Inflammation in tissues surrounding hormone receptors blocks their ability to bind to hormones, resulting in disrupted signaling and impaired hormone function. This is particularly relevant in conditions such as autoimmune diseases, where chronic inflammation targets specific tissues and causes damage.14

This can result in hormonal imbalances, which can manifest as symptoms like fatigue, weight gain, irregular menstrual cycles, mood swings, and many others. If left unmanaged, these imbalances often worsen over time and lead to serious health issues.15

The Results Of Hormone Dysfunction – Weight Gain

When there is an imbalance or dysfunction in hormones or their receptors, it can result in weight gain and difficulty in losing weight. For instance, studies have shown that individuals with hypothyroidism (an underactive thyroid gland) tend to have a slower metabolism, leading to weight gain. Similarly, imbalances in estrogen levels leads to increased fat storage, especially around the abdomen.16 17

On the other hand, insulin resistance, a condition where the body is unable to respond properly to insulin, leads to weight gain and difficulty in losing weight. This is because insulin plays a vital role in regulating fat metabolism and storing excess glucose as fat.18

In addition, testosterone levels also play a significant role in maintaining an optimal weight. Low levels of testosterone have been linked to an increase in body fat and difficulty in losing weight, particularly in men.19

How Come I Can’t Lose Weight Even Though I Diet And Exercise?

Many people focus solely on diet and exercise when trying to lose weight, but if the hormones are not functioning properly, these efforts are in vain.

As mentioned previously, insulin plays a significant role in weight loss. When we consistently consume a diet high in refined carbohydrates and sugars, our body produces more insulin than necessary, which can eventually lead to insulin resistance. This means that the cells become less responsive to insulin's message, and as a result, the body stores more fat.20

Another hormone that impacts weight loss is cortisol. Cortisol is known as the stress hormone and is released by the body in response to stress. When we experience chronic, ongoing stress, our cortisol levels remain elevated, leading to an increase in appetite and cravings for unhealthy foods. It also causes the body to store more fat, particularly in the abdominal area.21

Furthermore, hormones like leptin and ghrelin, known as hunger hormones, play a role in our appetite and food intake. Leptin signals to the brain when we are full and should stop eating, while ghrelin stimulates our appetite. When these hormones are imbalanced, it leads to overeating and weight gain.22

Restoring Cellular Energy - Hormone Imbalances

Restoring Cellular Energy – Optimizing Mitochondrial Function

There are steps we can take to improve mitochondrial function and restore cellular energy after we have already removed toxins from our life discussed in R1 and regenerated the cellular membrane discussed in R2.

Mitochondria Optimization And The Proper Diet

Mitochondria require a variety of nutrients to function optimally. These include B vitamins, magnesium, iron, and zinc. Eating a balanced diet that includes plenty of fruits, vegetables, grass-fed meat, fish rich in omega-3 fatty acids, nuts, and seeds ensure that your mitochondria have the necessary resources to produce ATP.23

Read more about my Cellular Healing Diet.

Mitochondria Optimization And Exercise

Regular physical activity has been shown to increase mitochondrial biogenesis, which is the creation of new mitochondria in cells. This means more powerhouses in your cells. Aim for at least 30 minutes of moderate exercise per day, such as brisk walking, cycling or swimming.24

Additionally, perform HIIT exercise for maximal mitochondrial biogenesis. HIIT workouts involve alternating periods of intense exercise with short rest periods, challenging the body to work at high intensity levels and promoting improvements in cardiovascular endurance and muscle strength.25

Mitochondria Optimization And Stress Reduction

Chronic stress leads to the production of free radicals, which damage mitochondria and affect their function. Finding ways to manage stress, such as meditation, yoga or deep breathing exercises, helps protect your mitochondria from oxidative damage.26

Mitochondria Optimization And Adequate Sleep

Sleep is crucial for cellular energy production and the repair and maintenance of mitochondria. Aim for 7-9 hours of quality sleep per night to allow your cells enough time to rest and recharge.27

R3 – Restoring Cellular Energy

After R3 – Restoring Cellular Energy, R2 – Regenerating The Cellular Membrane, and R1 – Removing The Source Of Toxins, it’s time to move onto the next step.

R4 – Reducing Cellular Inflammation

References

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2 Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92. doi: 10.1093/jn/134.3.489. PMID: 14988435.

3 Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019 Sep 3;11(9):2073. doi: 10.3390/nu11092073. PMID: 31484368; PMCID: PMC6770193.

4 Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009 Jul;8(8):697-701. doi: 10.1016/j.autrev.2009.02.020. Epub 2009 Feb 13. PMID: 19393193.

5 Xu Z, Zhang D, He X, Huang Y, Shao H. Transport of Calcium Ions into Mitochondria. Curr Genomics. 2016 Jun;17(3):215-9. doi: 10.2174/1389202917666160202215748. PMID: 27252588; PMCID: PMC4869008.

6 Santos JH. Mitochondria signaling to the epigenome: A novel role for an old organelle. Free Radic Biol Med. 2021 Jul;170:59-69. doi: 10.1016/j.freeradbiomed.2020.11.016. Epub 2020 Dec 1. PMID: 33271282; PMCID: PMC8166959.

7 Fang J, Wong HS, Brand MD. Production of superoxide and hydrogen peroxide in the mitochondrial matrix is dominated by site IQ of complex I in diverse cell lines. Redox Biol. 2020 Oct;37:101722. doi: 10.1016/j.redox.2020.101722. Epub 2020 Sep 14. PMID: 32971363; PMCID: PMC7511732.

8 Kotrys AV, Szczesny RJ. Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology. Cells. 2019 Dec 19;9(1):17. doi: 10.3390/cells9010017. PMID: 31861673; PMCID: PMC7017415.

9 Johnson TA, Jinnah HA, Kamatani N. Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP. Front Pharmacol. 2019 Feb 19;10:98. doi: 10.3389/fphar.2019.00098. PMID: 30837873; PMCID: PMC6390775.

10 Hiller-Sturmhöfel S, Bartke A. The endocrine system: an overview. Alcohol Health Res World. 1998;22(3):153-64. PMID: 15706790; PMCID: PMC6761896.

11 Hill M, Třískala Z, Honců P, Krejčí M, Kajzar J, Bičíková M, Ondřejíková L, Jandová D, Sterzl I. Aging, hormones and receptors. Physiol Res. 2020 Sep 30;69(Suppl 2):S255-S272. doi: 10.33549/physiolres.934523. PMID: 33094624; PMCID: PMC8603729.

12 Mendoza A, Hollenberg AN. New insights into thyroid hormone action. Pharmacol Ther. 2017 May;173:135-145. doi: 10.1016/j.pharmthera.2017.02.012. Epub 2017 Feb 4. PMID: 28174093; PMCID: PMC5407910.

13 Nussey S, Whitehead S. Endocrinology: An Integrated Approach. Oxford: BIOS Scientific Publishers; 2001. Chapter 1, Principles of endocrinology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK20/

14 Straub RH. Interaction of the endocrine system with inflammation: a function of energy and volume regulation. Arthritis Res Ther. 2014 Feb 13;16(1):203. doi: 10.1186/ar4484. PMID: 24524669; PMCID: PMC3978663.

15 Lund J, Lund C, Morville T, Clemmensen C. The unidentified hormonal defense against weight gain. PLoS Biol. 2020 Feb 25;18(2):e3000629. doi: 10.1371/journal.pbio.3000629. PMID: 32097406; PMCID: PMC7041792.

16 Alidrisi HA, Odhaib SA, Altemimi MT, Mansour AA. Patterns of Bodyweight Changes in Patients With Hypothyroidism, a Retrospective Study From Basrah, Southern Iraq. Cureus. 2021 Jun 2;13(6):e15408. doi: 10.7759/cureus.15408. PMID: 34262799; PMCID: PMC8259075.

17 Vigil P, Meléndez J, Petkovic G, Del Río JP. The importance of estradiol for body weight regulation in women. Front Endocrinol (Lausanne). 2022 Nov 7;13:951186. doi: 10.3389/fendo.2022.951186. PMID: 36419765; PMCID: PMC9677105.

18 Verkouter I, Noordam R, le Cessie S, van Dam RM, Lamb HJ, Rosendaal FR, van Heemst D, de Mutsert R. The Association between Adult Weight Gain and Insulin Resistance at Middle Age: Mediation by Visceral Fat and Liver Fat. J Clin Med. 2019 Sep 28;8(10):1559. doi: 10.3390/jcm8101559. PMID: 31569345; PMCID: PMC6832997.

19 Fui MN, Dupuis P, Grossmann M. Lowered testosterone in male obesity: mechanisms, morbidity and management. Asian J Androl. 2014 Mar-Apr;16(2):223-31. doi: 10.4103/1008-682X.122365. PMID: 24407187; PMCID: PMC3955331.

20 Chiu CJ, Wray LA, Beverly EA. Relationship of glucose regulation to changes in weight: a systematic review and guide to future research. Diabetes Metab Res Rev. 2010 Jul;26(5):323-35. doi: 10.1002/dmrr.1095. PMID: 20578206.

21 Hewagalamulage SD, Lee TK, Clarke IJ, Henry BA. Stress, cortisol, and obesity: a role for cortisol responsiveness in identifying individuals prone to obesity. Domest Anim Endocrinol. 2016 Jul;56 Suppl:S112-20. doi: 10.1016/j.domaniend.2016.03.004. Epub 2016 Mar 31. PMID: 27345309.

22 Hajishizari S, Imani H, Mehranfar S, Saeed Yekaninejad M, Mirzababaei A, Clark CCT, Mirzaei K. The association of appetite and hormones (leptin, ghrelin, and Insulin) with resting metabolic rate in overweight/ obese women: a case-control study. BMC Nutr. 2022 Apr 29;8(1):37. doi: 10.1186/s40795-022-00531-w. PMID: 35484608; PMCID: PMC9052687.

23 Kyriazis ID, Vassi E, Alvanou M, Angelakis C, Skaperda Z, Tekos F, Garikipati VNS, Spandidos DA, Kouretas D. The impact of diet upon mitochondrial physiology (Review). Int J Mol Med. 2022 Nov;50(5):135. doi: 10.3892/ijmm.2022.5191. Epub 2022 Sep 21. PMID: 36129147; PMCID: PMC9542544.

24 Sorriento D, Di Vaia E, Iaccarino G. Physical Exercise: A Novel Tool to Protect Mitochondrial Health. Front Physiol. 2021 Apr 27;12:660068. doi: 10.3389/fphys.2021.660068. PMID: 33986694; PMCID: PMC8110831.

25 Atakan MM, Li Y, Koşar ŞN, Turnagöl HH, Yan X. Evidence-Based Effects of High-Intensity Interval Training on Exercise Capacity and Health: A Review with Historical Perspective. Int J Environ Res Public Health. 2021 Jul 5;18(13):7201. doi: 10.3390/ijerph18137201. PMID: 34281138; PMCID: PMC8294064.

26 Picard M, McEwen BS. Psychological Stress and Mitochondria: A Systematic Review. Psychosom Med. 2018 Feb/Mar;80(2):141-153. doi: 10.1097/PSY.0000000000000545. PMID: 29389736; PMCID: PMC5901654.

27 Melhuish Beaupre LM, Brown GM, Braganza NA, Kennedy JL, Gonçalves VF. Mitochondria's role in sleep: Novel insights from sleep deprivation and restriction studies. World J Biol Psychiatry. 2022 Jan;23(1):1-13. doi: 10.1080/15622975.2021.1907723. Epub 2021 May 6. PMID: 33821750.

R2 Regenerating the Cell Membrane Omega 6 and Omega 3 Fatty Acid Ratio

R2 – Regenerating The Cellular Membrane

The cell membrane or lipid bilayer, which surrounds every cell in our body, acts as a protective barrier and controls what goes in and out of the cell. In order for our cells to effectively eliminate toxins, they must have a healthy and functional membrane.1

Embedded within the cell membrane are various types of proteins that act as receptors, channels, pumps, and enzymes. These proteins are responsible for receiving signals from the cell's environment, transporting substances in and out of the cell, and facilitating chemical reactions within the cell.2

For example, when a hormone binds to its specific receptor on the cellular membrane, it triggers a series of events that ultimately lead to a response from the cell. This response can range from changes in gene expression to altering the cell's shape and movement.3

Similarly, ion channels in the cellular membrane help maintain the cell's internal environment by regulating the flow of ions such as sodium, potassium, and calcium. This is important for functions like muscle contraction and nerve signaling.4

When everything is in balance, this system works like a well-oiled machine. However, when cellular inflammation is present, it impedes the function of membrane proteins. In order to regenerate the cellular membrane back to ideal form, toxins that cause inflammation must be eliminated.5

If you haven’t already, read more about R1 – removing the source of toxins that cause inflammation.

What Causes Cellular Membrane Inflammation?

Cellular membrane inflammation occurs when toxins such as heavy metals, mold, and hidden infections cause damage to the cellular membrane. When toxins breach this barrier, they disrupt essential processes within the cell, leading to inflammation. This inflammation contributes to various health issues, including allergies, autoimmune diseases, and hormone dysfunction.6

An Inflamed Cellular Membrane Affects Integral Membrane Proteins

One aspect that is affected by an inflamed cellular membrane is integral membrane proteins (IMP). These are specialized protein molecules that are embedded within the cellular membrane. They play crucial roles in cell signaling, transport of molecules, and maintaining the structural integrity of the cell.7

When the cellular membrane is inflamed, it disrupts the function and structure of integral membrane proteins. This is because inflammation causes changes in the composition and fluidity of the cellular membrane, which alters the positioning and conformation of IMPs. As a result, their ability to perform essential functions is compromised.8

Moreover, inflamed cellular membranes also lead to increased permeability, allowing molecules that are typically not allowed to enter the cell to pass through. This is dangerous as it allows harmful substances or pathogens to enter the cell and cause damage.9

Regenerating The Cellular Membrane - Integral Membrane Proteins

Cellular Membrane Inflammation Reduces Transport Into And Out Of The Cell

When there is inflammation throughout the cellular membrane, it leads to nutrient deficiencies. This is because the cellular membrane regulates the passage of nutrients and other molecules into and out of the cell. Essential vitamins and minerals are not able to enter the cell properly, resulting in inadequate nutrition for cellular metabolism.

An inflamed membrane also causes difficulty in removing waste products from the cells. This leads to a buildup of toxins and metabolic waste, further exacerbating the inflammation. As a result, cells are not able to function optimally, leading to tissue damage and various health issues.10

Inflammation of cellular membranes also affects cell signaling and communication. This is because cellular membranes play a crucial role in transmitting signals between cells and organ systems. When inflamed, these signals are not effectively transmitted, leading to disruptions in normal body functions.11

Furthermore, chronic inflammation of cellular membranes is known to contribute to the development of certain diseases and conditions such as atherosclerosis, rheumatoid arthritis, and various autoimmune disorders. It has also been linked to premature aging and increased risk of chronic diseases.12 13

Dr. Bruce Lipton’s Discovery Between Innate Intelligence And The Cellular Membrane

Dr. Bruce Lipton is a well-known cellular biologist who has been studying the effects of the cell membrane on gene expression for decades. His groundbreaking research has challenged traditional notions of genetic determinism and shed light on how our environment and perceptions affect the expression of our genes.

One of Lipton's key findings is that the cell membrane is not just a protective barrier but also acts as an intelligent interface between the cell and its external environment. This means that the signals from our environment can directly influence the behavior of our cells.14

At the core of Lipton's research is the concept of epigenetics, which refers to changes in gene expression without any alteration in the underlying DNA sequence. He has shown that the cell membrane is responsible for controlling which genes are turned on or off, and this can be influenced by various environmental factors such as nutrition, stress, and emotions.15

Lipton's research dictates that our perceptions and beliefs can override genetic predispositions and have a significant impact on our health and well-being. For example, stress and negative emotions lead to changes in the cell membrane, which affect gene expression. This means that our thoughts, attitudes, and perceptions directly influence our biology at the cellular level.

Simply put, positive emotions and a healthy environment help to keep the cell membrane in an optimal state, promoting the expression of beneficial genes.

A Dysfunctional Cellular Membrane Leads To Undesirable Gene Expression

When the cellular membrane becomes dysfunctional, it affects the signaling pathways that control gene expression. These pathways rely on specific molecules called signaling molecules to communicate with the cell's nucleus and activate or suppress certain genes. If the cellular membrane is compromised, these signaling molecules are not able to properly reach their intended target, resulting in altered gene expression.16

A dysfunctional cellular membrane leads to oxidative stress, which is an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify them. Oxidative stress damages DNA and epigenetic modifications, resulting in changes in gene expression.17

This is why regenerating the cellular membrane to an ideal state is so foundationally important to achieving good health. A properly functioning cellular membrane initiates the cell to turn on good genes and turn off bad genes, ensuring your best genetic traits are expressed.

Regenerating The Mitochondrial Membrane – ATP Energy Is Required To Detox The Cell

Mitochondria are known as the powerhouse of our cells, responsible for generating ATP (adenosine triphosphate), which is the main source of cellular energy. However, when the mitochondrial membrane becomes inflamed, it disrupts the normal functioning of mitochondria and leads to a decrease in energy production.18

To prevent this, it is important to understand the causes of mitochondrial membrane inflammation and how we can reduce it. One of the main causes is oxidative stress. Antioxidants help neutralize these free radicals, protecting the mitochondrial membrane from inflammation.19

Another factor that contributes to mitochondrial membrane inflammation is a high sugar and processed food diet. These types of foods result in oxidative stress and also lead to insulin resistance, which can further damage the mitochondria. It is important to maintain a balanced and healthy diet to support optimal mitochondrial function.20

In addition to reducing inflammation, it is important to support the repair and regeneration of the mitochondrial membrane. This can be done through exercise, specifically HIIT exercise, which has been shown to improve mitochondrial function and reduce inflammation in the body.21

Regenerating The Mitochondrial Membrane - ATP Energy Is Required To Detox The Cell

The Process Of Regenerating The Cellular Membrane

In a process called lipid synthesis, the cell is able to produce new phospholipids and incorporate them into the damaged membrane. This process involves enzymes and other proteins that work together to build the phospholipids from smaller molecules such as fatty acids. The newly synthesized lipids are then transported to the site of damage in the membrane where they can seamlessly integrate and repair any gaps or ruptures.22

The Composition Of The Cellular Membrane

Omega-6 and omega-3 fatty acids play important roles in maintaining the fluidity and permeability of the cellular membrane. Omega-6 and omega-3 are both polyunsaturated fatty acids (PUFAs), meaning they have multiple double bonds in their chemical structure. These fatty acids cannot be produced by our bodies and must be obtained through our diet.23

The balance between these two types of fats is crucial for the proper functioning of the cellular membrane. Too much omega-6 fatty acids in proportion to omega-3 can lead to increased inflammation and decreased fluidity of the membrane. This can affect the ability of substances to pass through the membrane and disrupt important cellular processes.24

On the other hand, the proper proportion of omega-3 fatty acids can improve the fluidity of the membrane and regulate inflammatory responses, leading to better overall health. Studies have also shown that the consumption of adequate amounts of omega-3 fatty acids improve cell signaling and communication.25

The traditional Western diet tends to be high in omega-6 fatty acids due to the widespread consumption of processed foods and vegetable oils. However, research has shown that an imbalanced ratio of omega-6 to omega-3 can increase the risk of chronic diseases. Even worse, processed vegetable oils often contain rancid omega-6 fatty acids. Consuming rancid omega-6 oils are linked with chronic inflammation and a long list of diseases.26 27

What Diet Provides High Quality Omega-6 And Omega-3 Fatty Acids?

High Quality Omega-3 Fatty Acid Foods

Consuming whole, unprocessed foods with sources of omega-3 fatty acids into our diet, such as fatty fish like salmon, sardines, and mackerel, as well as plant-based sources like chia seeds, flaxseeds, and walnuts are essential for cellular membrane function.28

High Quality Omega-6 Fatty Acid Foods

Nuts and seeds are excellent sources of omega-6 fatty acids. Some of the best options include walnuts, almonds, pumpkin seeds, and sunflower seeds. These foods not only provide omega-6 fatty acids, but also contain other beneficial nutrients like fiber, protein, and antioxidants.29

Avocado is another great source of omega-6 fatty acids. In addition to providing healthy fats, avocados also contain vitamins, minerals, and antioxidants that support heart health and reduce inflammation.30

Olive oil is a staple in the Mediterranean diet and is known for its many health benefits. It is a good source of omega-6 fatty acids, as well as monounsaturated fats which have been linked to improved heart health.31

Grass-fed meat is a great source of omega-6 fatty acids, as well as other important nutrients like protein and iron. Grass-fed meat also contains high quantities of conjugated linoleic acid (CLA) which helps us build muscle and burn fat.32 33

Flaxseeds are an excellent plant-based source of omega-6 fatty acids. They also contain high levels of fiber and antioxidants, making them a nutritious addition to any diet. Similar to flaxseeds, chia seeds are also a great plant-based source of omega-6 fatty acids.34

Regenerating The Cellular Membrane With My Cellular Healing Diet

Regenerating The Cellular Membrane With My Cellular Healing Diet

My Cellular Healing Diet provides the body with the products required to repair the lipid bilayer like healthy omega-6 and omega-3 fatty acids from real, whole foods. By incorporating a diet with the build blocks for cellular membrane repair, the body systemically regenerates cellular membranes.

Simply put, if we remove the toxins presented in R1 and provide the building blocks for R2 – Regenerating The Cellular Membrane, the body is able to heal itself.

Now it is time for R3 – Restoring Cellular Energy.

References

1 Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. The Lipid Bilayer. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26871/

2 Qiu W, Fu Z, Xu GG, Grassucci RA, Zhang Y, Frank J, Hendrickson WA, Guo Y. Structure and activity of lipid bilayer within a membrane-protein transporter. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12985-12990. doi: 10.1073/pnas.1812526115. Epub 2018 Dec 3. PMID: 30509977; PMCID: PMC6304963.

3 Robertson JL. The lipid bilayer membrane and its protein constituents. J Gen Physiol. 2018 Nov 5;150(11):1472-1483. doi: 10.1085/jgp.201812153. Epub 2018 Sep 25. PMID: 30254021; PMCID: PMC6219687.

4 Levitan I, Fang Y, Rosenhouse-Dantsker A, Romanenko V. Cholesterol and ion channels. Subcell Biochem. 2010;51:509-49. doi: 10.1007/978-90-481-8622-8_19. PMID: 20213557; PMCID: PMC2895485.

5 Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. PMID: 29467962; PMCID: PMC5805548.

6 Langan D, Rose NR, Moudgil KD. Common innate pathways to autoimmune disease. Clin Immunol. 2020 Mar;212:108361. doi: 10.1016/j.clim.2020.108361. Epub 2020 Feb 10. PMID: 32058071; PMCID: PMC8324042.

7 Majeed S, Ahmad AB, Sehar U, Georgieva ER. Lipid Membrane Mimetics in Functional and Structural Studies of Integral Membrane Proteins. Membranes (Basel). 2021 Sep 3;11(9):685. doi: 10.3390/membranes11090685. PMID: 34564502; PMCID: PMC8470526.

8 de Groot NS, Burgas MT. Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? Cell Mol Life Sci. 2015 Dec;72(24):4795-805. doi: 10.1007/s00018-015-2038-4. Epub 2015 Sep 24. PMID: 26403788; PMCID: PMC5005413.

9 Bednarek R. In Vitro Methods for Measuring the Permeability of Cell Monolayers. Methods Protoc. 2022 Feb 9;5(1):17. doi: 10.3390/mps5010017. PMID: 35200533; PMCID: PMC8874757.

10 Ammendolia, D.A., Bement, W.M. & Brumell, J.H. Plasma membrane integrity: implications for health and disease. BMC Biol 19, 71 (2021). https://doi.org/10.1186/s12915-021-00972-y

11 Bender EC, Kraynak CA, Huang W, Suggs LJ. Cell-Inspired Biomaterials for Modulating Inflammation. Tissue Eng Part B Rev. 2022 Apr;28(2):279-294. doi: 10.1089/ten.TEB.2020.0276. Epub 2021 Jul 29. PMID: 33528306; PMCID: PMC9063153.

12 Duan L, Rao X, Sigdel KR. Regulation of Inflammation in Autoimmune Disease. J Immunol Res. 2019 Feb 28;2019:7403796. doi: 10.1155/2019/7403796. PMID: 30944837; PMCID: PMC6421792.

13 Pahwa R, Goyal A, Jialal I. Chronic Inflammation. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/

14 Gustafson C. Bruce Lipton, PhD: The Jump From Cell Culture to Consciousness. Integr Med (Encinitas). 2017 Dec;16(6):44-50. PMID: 30936816; PMCID: PMC6438088.

15 Virgallito, L. (2021, November 30). How our thoughts control our DNA. Bruce H. Lipton, PhD. https://www.brucelipton.com/how-our-thoughts-control-our-dna/

16 Smith M, Flodman PL. Expanded Insights Into Mechanisms of Gene Expression and Disease Related Disruptions. Front Mol Biosci. 2018 Nov 27;5:101. doi: 10.3389/fmolb.2018.00101. PMID: 30542652; PMCID: PMC6277798.

17 Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. Int J Mol Sci. 2021 Apr 28;22(9):4642. doi: 10.3390/ijms22094642. PMID: 33924958; PMCID: PMC8125527.

18 Cojocaru KA, Luchian I, Goriuc A, Antoci LM, Ciobanu CG, Popescu R, Vlad CE, Blaj M, Foia LG. Mitochondrial Dysfunction, Oxidative Stress, and Therapeutic Strategies in Diabetes, Obesity, and Cardiovascular Disease. Antioxidants (Basel). 2023 Mar 7;12(3):658. doi: 10.3390/antiox12030658. PMID: 36978905; PMCID: PMC10045078.

19 Huang ML, Chiang S, Kalinowski DS, Bae DH, Sahni S, Richardson DR. The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis. Oxid Med Cell Longev. 2019 Apr 7;2019:6392763. doi: 10.1155/2019/6392763. PMID: 31057691; PMCID: PMC6476015.

20 Kyriazis ID, Vassi E, Alvanou M, Angelakis C, Skaperda Z, Tekos F, Garikipati VNS, Spandidos DA, Kouretas D. The impact of diet upon mitochondrial physiology (Review). Int J Mol Med. 2022 Nov;50(5):135. doi: 10.3892/ijmm.2022.5191. Epub 2022 Sep 21. PMID: 36129147; PMCID: PMC9542544.

21 Chou CH, Fu TC, Tsai HH, Hsu CC, Wang CH, Wang JS. High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure. Int J Cardiol. 2019 Jan 1;274:214-220. doi: 10.1016/j.ijcard.2018.07.104. Epub 2018 Jul 27. PMID: 30072155.

22 Cockcroft S. Mammalian lipids: structure, synthesis and function. Essays Biochem. 2021 Nov 2;65(5):813-845. doi: 10.1042/EBC20200067. PMID: 34415021; PMCID: PMC8578989.

23 Fuentes NR, Kim E, Fan YY, Chapkin RS. Omega-3 fatty acids, membrane remodeling and cancer prevention. Mol Aspects Med. 2018 Dec;64:79-91. doi: 10.1016/j.mam.2018.04.001. Epub 2018 Apr 12. PMID: 29627343; PMCID: PMC6185832.

24 Cotogni P, Muzio G, Trombetta A, Ranieri VM, Canuto RA. Impact of the omega-3 to omega-6 polyunsaturated fatty acid ratio on cytokine release in human alveolar cells. JPEN J Parenter Enteral Nutr. 2011 Jan;35(1):114-21. doi: 10.1177/0148607110372392. PMID: 21224438.

25 Valentine RC, Valentine DL. Omega-3 fatty acids in cellular membranes: a unified concept. Prog Lipid Res. 2004 Sep;43(5):383-402. doi: 10.1016/j.plipres.2004.05.004. PMID: 15458813.

26 Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C. Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426. doi: 10.1155/2012/539426. Epub 2012 Apr 5. PMID: 22570770; PMCID: PMC3335257.

27 DiNicolantonio JJ, O'Keefe JH. Omega-6 vegetable oils as a driver of coronary heart disease: the oxidized linoleic acid hypothesis. Open Heart. 2018 Sep 26;5(2):e000898. doi: 10.1136/openhrt-2018-000898. PMID: 30364556; PMCID: PMC6196963.

28 Innes JK, Calder PC. Marine Omega-3 (N-3) Fatty Acids for Cardiovascular Health: An Update for 2020. Int J Mol Sci. 2020 Feb 18;21(4):1362. doi: 10.3390/ijms21041362. PMID: 32085487; PMCID: PMC7072971.

29 DiNicolantonio JJ, O'Keefe J. The Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing the Risk of Autoimmune Diseases, Asthma, and Allergies. Mo Med. 2021 Sep-Oct;118(5):453-459. PMID: 34658440; PMCID: PMC8504498.

30 Dreher ML, Davenport AJ. Hass avocado composition and potential health effects. Crit Rev Food Sci Nutr. 2013;53(7):738-50. doi: 10.1080/10408398.2011.556759. PMID: 23638933; PMCID: PMC3664913.

31 Schwingshackl L, Hoffmann G. Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies. Lipids Health Dis. 2014 Oct 1;13:154. doi: 10.1186/1476-511X-13-154. PMID: 25274026; PMCID: PMC4198773.

32 Nogoy KMC, Sun B, Shin S, Lee Y, Zi Li X, Choi SH, Park S. Fatty Acid Composition of Grain- and Grass-Fed Beef and Their Nutritional Value and Health Implication. Food Sci Anim Resour. 2022 Jan;42(1):18-33. doi: 10.5851/kosfa.2021.e73. Epub 2022 Jan 1. PMID: 35028571; PMCID: PMC8728510.

33 Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutr J. 2010 Mar 10;9:10. doi: 10.1186/1475-2891-9-10. PMID: 20219103; PMCID: PMC2846864.

34 Parikh M, Maddaford TG, Austria JA, Aliani M, Netticadan T, Pierce GN. Dietary Flaxseed as a Strategy for Improving Human Health. Nutrients. 2019 May 25;11(5):1171. doi: 10.3390/nu11051171. PMID: 31130604; PMCID: PMC6567199.

R1 Removing The Source of Toxins

R1 – Remove The Source Of Toxins

Fix the cell and you will get well.

When our cells are not functioning properly, our overall health suffers, leading to chronic disease. The first step of fixing the cell is to remove the source of toxins responsible for cellular dysfunction. By addressing the toxins that made us sick in the first place, we are removing the root cause of health issues at the most basic level, the cellular level.

Toxins Are All Around Us

Toxins come from a variety of sources in the air we breathe, the food we eat, the medical procedures we undergo, and even the products we use on a daily basis. These toxins accumulate in our cells over time, leading to cellular dysfunction and ultimately, various health problems like hormone issues and autoimmune conditions.1 2

The first step towards fixing the cell is to identify and remove the sources of toxins. Before anything else, we must stop or at least significantly reduce the influx of toxins that are flowing into our bodies. After that, we can focus on removing the cellular toxins that have built up within us over decades.

The three main toxins responsible for systemic cellular dysfunction include heavy metals, exposure to mold, and hidden infections.3 4 5 Other toxins that degrade cellular function include BPA, phthalates, bromine, and chlorine, to name a few.6 7 8 9

If we ever want to experience true health, we must consciously avoid toxins.

Remove The Source Of Toxins

Remove The Source Of Toxins – Heavy Metals

Heavy metals include lead, mercury, arsenic, and cadmium. Heavy metal contamination is widespread and occurs through various sources such as industrial waste, agricultural runoff, and even natural processes like erosion. Heavy metals are often released into the air during mining, smelting, and the burning of fossil fuels.10

Remove The Source Of Toxins – Mercury In Seafood

One of the most common ways people are exposed to mercury is through consuming contaminated fish and seafood. Mercury can accumulate in the bodies of fish and other marine life, especially larger predatory species like tuna, swordfish, and shark. This is because they consume smaller fish that have already absorbed mercury from the water.11

Remove The Source Of Toxins – Mercury Amalgam Fillings

Mercury amalgam fillings, also known as silver fillings, have been used for decades as a popular choice for dental restorations. They are made up of a mixture of metals, including silver, tin, copper, and approximately 50% mercury.12

The major issue with mercury amalgam fillings is that they continuously release small amounts of mercury vapor. This can happen through normal chewing and grinding of teeth, as well as exposure to hot liquids and acidic foods. The released mercury vapor is then absorbed into the body through the lungs and reaches different organs, including the brain.13

Mercury is a neurotoxin that has been linked to cognitive issues such as memory loss, confusion, and difficulty concentrating. It also affects the immune system, leading to autoimmune disorders and allergies. In addition, mercury has been shown to have negative impacts on the cardiovascular and respiratory systems.14

Remove The Source Of Toxins - Mercury Amalgam Fillings

Remove The Source Of Toxins – Lead

Lead is also highly toxic to humans, causing serious health issues when ingested or inhaled. While lead-based paints were banned in the 1970s and leaded gasoline was phased out in the 1990s, lead exposure is still a major concern.15 16

Lead can leach into drinking water from old pipes or soldered joints, especially in older buildings. This is more common in areas with acidic or soft water, as it corrodes the pipes more quickly. The longer the water sits in contact with lead, the higher its levels will be.17 Lead exposure is particularly concerning in urban areas where there are many old buildings with peeling lead-based paint and potential sources of pollution.

Lead contamination in soil is a major concern for both human health and the environment. It originates from various sources such as industrial activities, improper disposal of lead-containing materials, or using fertilizers that contain high levels of lead.18

Lead is often found in various consumer products such as cosmetics, toys, jewelry, and even food containers. This is especially concerning for children who are more susceptible to lead poisoning due to their smaller size and tendency to put objects in their mouths.19

How Heavy Metals Affect Cells

The cellular membrane is a lipid bilayer (2 layers of fat) that surrounds cells and gives them their shape. When heavy metals are present, they result in cellular membrane inflammation that changes the basic structure of the lipid bilayer resulting in hormone receptor problems, autoimmune conditions, and a long list of chronic diseases. The only way to deal with all of these issues simultaneously is to remove heavy metals from the cells and out of the body.20

Removing Heavy Metals From The Cells

The process of removing heavy metals from the body requires dedication and patience, as the detox is measured in years, not months. My goal is to teach my clients the process of detoxification so they can remove the heavy metals from their cells and get their health back.

Heavy Metal Blood Tests Don’t Tell The Whole Story

Realize that typical heavy metal tests don't actually show intracellular levels of heavy metals, but rather blood levels. This means that the results obtained for heavy metal levels can be misleading.21

Removing Heavy Metals From The Cells – Chelation

Chelators are substances that bind to and excrete heavy metals. However, there are only a few ideal chelators that completely bind to and remove heavy metals from the body without redistributing them to other tissues. It is imperative to use the correct heavy metal chelators at the proper intervals, and for long enough to finally remove these horrible toxins from the body.22

Remove The Source Of Toxins – Mold Exposure

Toxic mold exposure is the second main source of toxins responsible for systemic cellular dysfunction. Exposure to toxic mold can occur through inhalation, ingestion, or even skin contact.23

One of the most common ways people are exposed to toxic mold is through their homes. Mold can grow in areas with high moisture, such as bathrooms, basements, and attics. If left untreated, mold can spread quickly and release harmful toxins into the air we breathe.24

Inhaling these toxins often leads to a variety of health issues, ranging from mild allergies to more serious respiratory problems. Some common symptoms of toxic mold exposure include coughing, sneezing, itchy eyes, runny nose, and throat irritation. In severe cases, toxic mold exposure can even cause lung infections or exacerbate existing respiratory conditions.25

Research has shown that prolonged exposure to mold toxins have neurological impacts, such as memory loss, difficulty concentrating, and mood changes. In some cases, toxic mold exposure has even been linked to chronic fatigue syndrome and depression.26 27

Remove The Source Of Toxins - Mold Exposure

Removing The Source Of Toxic Mold

If you suspect that your home may have a mold problem, it's important to contact a professional for proper removal and remediation. However, many people aren’t even aware that they have a mold problem so it is important to have your house or business professionally analyzed for mold. Attempting to remove mold on your own can actually make the situation worse, as disturbing the mold causes it to release more toxins into the air.

Remove The Source Of Toxins – Hidden Infections

Hidden infections refer to any type of infection that is not easily detectable. This can include chronic sinus infections, undiagnosed dental infections, and even gut imbalances such as SIBO (small intestinal bacterial overgrowth). These hidden infections cause a wide range of symptoms, from fatigue and brain fog to joint pain and digestive issues.28 29

Hidden infections can fly under the radar for years. Additionally, many people attribute their symptoms to other causes and don't consider the possibility of an underlying infection.

Remove The Source Of Toxins – Hidden Infections – Root Canals

Root canals are a common dental procedure that is used to save severely damaged or infected teeth. While it may seem like a solution for preserving your natural tooth, there is growing evidence that root canals may actually be harmful to your health.30

One of the main concerns with root canals is the potential for hidden infections. When a tooth becomes infected, the bacteria can travel down through the root canal and into the surrounding tissue, leading to a chronic infection.31

These hidden infections are particularly concerning because they release toxins into the bloodstream. These toxins compromise the immune system and lead to a variety of health issues, such as fatigue, joint pain, and even autoimmune diseases. Studies have also shown the connection between root canals and diseases such as heart disease and stroke.32

Remove The Source Of Toxins – Discover Hidden Infections – Cone Beam Computed Tomography

One of the most effective ways to detect hidden infections is through Cone Beam Computed Tomography (CBCT). CBCT is a specialized type of X-ray technology that produces three-dimensional images of the body's structures. This advanced imaging technique allows us to see beyond what a regular X-ray can capture, providing a more detailed and accurate diagnosis.

CBCT is particularly useful in detecting hidden infections in the jaw and oral cavity. CBCT scans can help identify underlying infections that may be causing this inflammation, allowing for targeted treatment to remove the source of toxins.33

Remove The Source Of Toxins - Discover Hidden Infections - Cone Beam Computed Tomography

R1 – Remove The Source Of Toxins

Removing the source of toxins is the first step in addressing chronic illnesses. As soon as we remove the root of our health problems, we can move on to the next step.

R2 – Regenerating The Cellular Membrane

References

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